抗p15 INK4b抗体 | Anti-p15 INK4b antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

	IHC-P analysis of formalin fixed human lung cancer tissue section using GTX55855 p15 INK4b antibody.Antigen retrieval : Heat mediated antigen retrieval with sodium citrate buffer (pH 6.0)
	ICC/IF analysis of formalin-fixed A549 cells using GTX55855 p15 INK4b antibody.Red : Primary antibodyBlue : DAPI Permeabilization : 0.1% Triton X-100 in TBS for 5-10 minutes
	WB analysis of HepG2 (A), A549 (B), HeLa (C), mouse brain (D), rat kidney (E) whole cell lysates using GTX55855 p15 INK4b antibody.

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, ICC/IF, IHC-P
Reactivity	Human, Mouse, Rat

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	1:500 - 1:1000
ICC/IF	1:100 - 1:500
IHC-P	1:100 - 1:200

Not tested in other applications.

Calculated MW	15 kDa. ( Note )

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PROPERTIES

Form	Liquid
Buffer	0.42% Potassium phosphate, 0.87% Sodium chloride pH 7.3, 30% glycerol, 0.01% sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20º C or below. Avoid multiple freeze-thaw cycles.
Concentration	Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of p15 INK4b. The exact sequence is proprietary.
Purification	Purified by antigen-affinity chromatography
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	cyclin dependent kinase inhibitor 2B , CDK4I , INK4B , MTS2 , P15 , TP15 , p15INK4b
Cellular Localization	Cytoplasm
Background	This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Database	・ Gene ID: 1030 CDKN2B ・ UniProt: P42772 CDKN2B

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