抗Her2 / ErbB2 [ERB2/776]抗体 | Anti-Her2 / ErbB2 [ERB2/776] antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

	ICC/IF analysis of MCF-7 cells using GTX34781 Her2 / ErbB2 antibody [ERB2/776]. Green : Primary antibodyRed : nucleus
	FACS analysis of trypsinized MCF-7 cells using GTX34781 Her2 / ErbB2 antibody [ERB2/776]. Blue : Primary antibodyRed : Isotype control

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	ERB2/776
Isotype	IgG1
Application	ICC/IF, FACS, ELISA
Reactivity	Human

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
ICC/IF	1-2μg/ml
FACS	1-2μg/10⁶ cells
ELISA	Assay dependent
Note : ELISA For ELISA coating, recommend using BSA-free format (please contact us for PBS only format).

Not tested in other applications.

Calculated MW	138 kDa. ( Note )
Specificity/Sensitivity	This MAb is specific to c-erbB-2/HER-2 and shows minimal cross-reaction with other members of the family.

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PROPERTIES

Form	Liquid
Buffer	10mM PBS, 0.05% BSA, 0.05% sodium azide (Please contact us for PBS only format)
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	0.2 mg/ml
Antigen Species	Human
Immunogen	Recombinant intracellular domain of human HER-2 protein
Purification	Protein A/G purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	CD340,ERBB2,HER2,HER2/neu,MLN 19,NEU,NGL,TKR1,erbb2 receptor tyrosine kinase 2,Her2,ErbB2,Neu,EGFR2,erb-b2 receptor tyrosine kinase 2
Cellular Localization	Cell membrane,Cytoplasm,Perinuclear region,Nucleus
Background	This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Database	・ Gene ID: 2064 ERBB2 ・ UniProt: P04626 ERBB2

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