抗Hemagglutinin 5 [H5.3]組換え抗体 | Anti-Hemagglutinin 5 [H5.3] recombinant antibody
掲載日情報:2019/10/24 現在Webページ番号:218926
Absolute Antibody社の抗Hemagglutinin 5 [H5.3]組換え抗体(リコンビナント抗体)( Anti-Hemagglutinin 5 [H5.3] recombinant antibody)です。
※本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 :2024年09月22日 00時00分現在]
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Anti-Hemagglutinin 5, Human IgG1, Fc Silent, Recombinant Monoclonal Antibody, clone H5.3 |
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Anti-Hemagglutinin 5, Human IgG1, Fc Silent, Recombinant Monoclonal Antibody, clone H5.3 |
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[在庫・価格 :2024年09月22日 00時00分現在]
Anti-Hemagglutinin 5, Human IgG1, Fc Silent, Recombinant Monoclonal Antibody, clone H5.3
文献数: 0
- 商品コード:Ab00798-10.3
- メーカー:ABA
- 包装:0.2mg
- 価格:¥148,000
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 組換え体抗体。Azide Free。バッファー組成:PBS with 0.02% Proclin 300. 別名:H5 HA クローン:H5.3 |
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保存条件 | 法規備考 | ||
抗原種 | 免疫動物 | Human | |
交差性 | 1203/156/Anhui/HK/Indo)/Influenza virus H5N1 (VN | 適用 | Neutralising |
標識 | Unlabeled | 性状 | Protein A/G Affinity Purified |
吸収処理 | クラス | IgG | |
クロナリティ | Recombinant | フォーマット | |
掲載カタログ |
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製品記事 | Fc Silent組換え抗体 | Fc Silent recombinant antibody 技術情報:抗体のFcドメインのタンパク質工学的改変 |
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関連記事 |
Anti-Hemagglutinin 5, Human IgG1, Fc Silent, Recombinant Monoclonal Antibody, clone H5.3
文献数: 0
- 商品コード:Ab00798-10.3-BT
- メーカー:ABA
- 包装:1mg
- 価格:ご照会ください
- 在庫:無(未発注)
- 納期:2~3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等:
説明文 | 組換え体抗体。Azide Free。バッファー組成:PBS only. 別名:H5 HA クローン:H5.3 |
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法規制等 | |||
保存条件 | 法規備考 | ||
抗原種 | 免疫動物 | Human | |
交差性 | 1203/156/Anhui/HK/Indo)/Influenza virus H5N1 (VN | 適用 | Neutralising |
標識 | Unlabeled | 性状 | Protein A/G Affinity Purified |
吸収処理 | クラス | IgG | |
クロナリティ | Recombinant | フォーマット | |
掲載カタログ |
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製品記事 | Fc Silent組換え抗体 | Fc Silent recombinant antibody 技術情報:抗体のFcドメインのタンパク質工学的改変 |
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関連記事 |
追加しました。
製品情報
Description | Recombinant monoclonal antibody to Hemagglutinin 5. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma H5.3. This antibody was created using our proprietary Fc Silent™ engineered Fc domain containing key point mutations that abrogate binding to Fc gamma receptors. This reformatted human antibody was made using the variable domain sequences of the original Human IgG format, for improved compatibility with existing reagents, assays and techniques. |
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Species and Isotype | Human IgG1, Fc Silent™, lambda |
Clone Number | H5.3 |
UniProt Accession Number of Target Protein | Q5EP31 |
Published Application(s) | Neutralize |
Published Species Reactivity | Influenza virus H5N1 (VN/1203; HK/156; Anhui; Indo) |
Immunogen | H5.3 was generated from hybridomas created by fusing PBMCs (peripheral blood mononuclear cells) from human donors who had been previously received an A/Vietnam/1203/2004 H5N1 subunit vaccine with myeloma cells. The hybridoma cells were screened for those showing binding affinity for H5 HA. |
Specificity | H5.3 binds to H5 at the head domain at an epitope which involves the 190 loop. The epitope was determined to be LGVSSA (aa 134-139) and YQGKSS (aa 142-147) of the head domain by DXMS (deuterium exchange mass spectrometry). This antibody shows reactivity with the wild-type H5N1 field strains VN/1203 (EC50 ~ 17 ng/ml), HK/156 (EC50 ~ 18 ng/ml), Anhui (EC50 ~ 2.8 ug/ml) and Indo (EC50 ~ 10 ug/ml). HA is a viral glycoprotein initially assembled as a trimer on the viral envelope as the preprotein HA0. It is subsequently cleaved by host proteases. |
Application Notes | H5.3 binds to H5 where it is able to block the receptor binding site on HA by inserting its CDR3 into the site (IC50 ~ 20 ng/ml). H5.3 can neutralize wild-type VN/1203, rdt VN/1203 K and VN/1203 F pseudovirions, all with IC50s of 5 ng/ml. This antibody also has potent HI (hemagglutination inhibition) activity (80 ng/ml). |
Antibody First Published in | Thornburg et al. Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses. J Clin Invest. 2013 Oct;123(10):4405-9. PMID:23999429 |
Note on publication | Describes the generation of anti-H5 HA antibodies. Their binding and neutralizing activities were studied in vitro. The structure of H5.3 was determined by x-ray crystallography and a low-resolution structure of H5.3 complexed with VN/1203 HA trimer was determined by EM. |
Purification | Protein A affinity purified |
Supplied in | Bulk size: PBS only. Standard size: PBS with 0.02% Proclin 300. |
Storage Recommendation | Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C |
Concentration | See vial label. |
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