SCF Protein 組換え体(リコンビナント)タンパク質 | Recombinant Human SCF Protein
掲載日情報：2018/02/07 現在Webページ番号：215992
R&D Systems社製の高品質なSCF Proteinの組換え体タンパク質(Recombinant Human SCF Protein)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年05月01日 12時15分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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[在庫・価格 ：2025年05月01日 12時15分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Recombinant Human SCF Protein
文献数： 0
- 商品コード：255-SC-01M
- メーカー：RSD
- 包装：1mg
- 価格：ご照会ください
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 純度：>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.，由来動物：Human，M.W.：18.6 kDa，Genbank：4254，エンドトキシンレベル：<1.0 EU per 1 µg of the protein by the LAL method.，産生：E. coli 別名：c-kit Ligand Genbank No： 4254 Protein Accession No： P21583.1 |
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| 保存条件 | -20℃ | 法規備考 | |
| 掲載カタログ |
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| 製品記事 | 抗幹細胞マーカー抗体／抗造血幹細胞マーカー抗体（R&D Systems社） |
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CF(Carrier-Free)とは？
R&D Systems社組換え体タンパク質製品では通常ウシ血清アルブミン(BSA)をキャリアタンパク質として加えています。キャリアタンパク質を加えることで組換え体タンパク質の安定性が高まり、使用期限が長くなります。また、より濃度の低い溶液での保管も可能となります。CF製品はBSAが含まれない製品となります。一般的に細胞培養や、ELISAのスタンダードにはBSA含有製品を推奨しています。CF製品はBSAが影響してしまうアプリケーションに推奨されます。
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Product Details
- Source
- E. coli-derivedGlu26-Ala189, with an N-terminal Met
- Accession #
- P21583.1
- Purity
- >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
- Predicted Molecular Mass
- 18.6 kDa
- Activity
- Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is 1‑5 ng/mL.The specific activity of Recombinant Human SCF is approximately 564IU/μg, which is calibrated against recombinant human SCF WHOInternational Standard (NIBSC code: 91/682).
- Bioactivity
- Recombinant Human SCF/c-kit Ligand (Catalog # 255-SC) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED50 for this effect is 1-5 ng/mL.
- SDS-PAGE
- 1 μg/lane of Recombinant Human SCF/c-kit Ligand was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 19 kDa.
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Related Product & Information
- Entrez Gene IDs
- 4254 (Human); 17311 (Mouse); 60427 (Rat); 403507 (Canine); 493937 (Feline)
- Background
- SCF/c-kit Ligand
- Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28‑40 kDa type I transmembrane glycoprotein (1). It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors (1‑7). SCF is a primary growth and activation factor for mast cells and eosinophils (8). Mature human SCF consists of a 189 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 36 aa cytoplasmic tail (9). The ECD shows both N‑linked and O-linked glycosylation (10). Proteolytic cleavage at two alternate sites in the extracellular juxtamembrane region releases a 25 kDa soluble molecule which is comparable to the only form produced by Steel-dickie mutant mice (11, 12). An alternately spliced isoform of human SCF lacks 28 aa that encompasses the primary proteolytic recognition site (13). Within the ECD of the long isoform (corresponding to this recombinant protein), human SCF shares 79%‑87% aa sequence identity with canine, feline, mouse, and rat SCF. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells (9). Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/c‑kit to trigger receptor dimerization and signaling (14). SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels (15).
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors
Authors: J Helft, F Anjos-Afon, AG van der Ve, P Chakravart, D Bonnet, C Reis E Sou
Cell Rep, 2017;20(3):529-537.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: J Helft, F Anjos-Afon, AG van der Ve, P Chakravart, D Bonnet, C Reis E Sou
Cell Rep, 2017;20(3):529-537.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Generation of human iPSCs from an essential thrombocythemia patient carrying a V501L mutation in the MPL gene
Authors: S Liu, Z Ye, Y Gao, C He, DW Williams, A Moliterno, J Spivak, H Huang, L Cheng
Stem Cell Res, 2017;18(0):57-59.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: S Liu, Z Ye, Y Gao, C He, DW Williams, A Moliterno, J Spivak, H Huang, L Cheng
Stem Cell Res, 2017;18(0):57-59.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens
Authors: I Baccelli, J Krosl, G Boucher, I Boivin, VP Lavallée, J Hébert, S Lemieux, A Marinier, G Sauvageau
Blood Cancer J, 2017;7(2):e529.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: I Baccelli, J Krosl, G Boucher, I Boivin, VP Lavallée, J Hébert, S Lemieux, A Marinier, G Sauvageau
Blood Cancer J, 2017;7(2):e529.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia
Authors: AG Kotini, CJ Chang, A Chow, H Yuan, TC Ho, T Wang, S Vora, A Solovyov, C Husser, M Olszewska, J Teruya-Fel, D Perumal, VM Klimek, A Spyridonid, RK Rampal, L Silverman, EP Reddy, E Papaemmanu, S Parekh, BD Greenbaum, CS Leslie, MG Kharas, EP Papapetrou
Cell Stem Cell, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: AG Kotini, CJ Chang, A Chow, H Yuan, TC Ho, T Wang, S Vora, A Solovyov, C Husser, M Olszewska, J Teruya-Fel, D Perumal, VM Klimek, A Spyridonid, RK Rampal, L Silverman, EP Reddy, E Papaemmanu, S Parekh, BD Greenbaum, CS Leslie, MG Kharas, EP Papapetrou
Cell Stem Cell, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Anti-KIT Monoclonal Antibody Treatment Enhances the Anti-Tumor Activity of Immune Checkpoint Inhibitors by Reversing Tumor-Induced Immunosuppression
Authors: AJ Garton, S Seibel, L Lopresti-M, L Crew, N Janson, S Mandiyan, ES Trombetta, S Pankratz, TM LaVallee, R Gedrich
Mol. Cancer Ther, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: AJ Garton, S Seibel, L Lopresti-M, L Crew, N Janson, S Mandiyan, ES Trombetta, S Pankratz, TM LaVallee, R Gedrich
Mol. Cancer Ther, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells
Authors: K Trakarnsan, RE Griffiths, MC Wilson, A Blair, TJ Satchwell, M Meinders, N Cogan, S Kupzig, R Kurita, Y Nakamura, AM Toye, DJ Anstee, J Frayne
Nat Commun, 2017;8(0):14750.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: K Trakarnsan, RE Griffiths, MC Wilson, A Blair, TJ Satchwell, M Meinders, N Cogan, S Kupzig, R Kurita, Y Nakamura, AM Toye, DJ Anstee, J Frayne
Nat Commun, 2017;8(0):14750.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis
Authors: L Butcher, M Ahluwalia, T Örd, J Johnston, RH Morris, E Kiss-Toth, T Örd, JD Erusalimsk
Sci Rep, 2017;7(1):6684.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: L Butcher, M Ahluwalia, T Örd, J Johnston, RH Morris, E Kiss-Toth, T Örd, JD Erusalimsk
Sci Rep, 2017;7(1):6684.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis
Authors: NJ Palpant, Y Wang, B Hadland, RJ Zaunbreche, M Redd, D Jones, L Pabon, R Jain, J Epstein, WL Ruzzo, Y Zheng, I Bernstein, A Margolin, CE Murry
Cell Rep, 2017;20(7):1597-1608.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: NJ Palpant, Y Wang, B Hadland, RJ Zaunbreche, M Redd, D Jones, L Pabon, R Jain, J Epstein, WL Ruzzo, Y Zheng, I Bernstein, A Margolin, CE Murry
Cell Rep, 2017;20(7):1597-1608.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A Potential Mechanism for ADC-Induced Neutropenia: Role of Neutrophils in Their Own Demise
Authors: H Zhao, S Gulesseria, MC Malinao, S Kumar-Gane, J Song, MS Chang, MM Williams, Z Zeng, M Mattie, BA Mendelsohn, DR Stover, F Doñate
Mol. Cancer Ther., 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: H Zhao, S Gulesseria, MC Malinao, S Kumar-Gane, J Song, MS Chang, MM Williams, Z Zeng, M Mattie, BA Mendelsohn, DR Stover, F Doñate
Mol. Cancer Ther., 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34(+) Cells for Correction of Fabry Disease
Authors: J Huang, A Khan, BC Au, DL Barber, L López-Vásq, NL Prokopishy, M Boutin, M Rothe, JW Rip, M Abaoui, MS Nagree, S Dworski, A Schambach, A Keating, ML West, J Klassen, PV Turner, S Sirrs, CA Rupar, C Auray-Blai, R Foley, JA Medin
Mol Ther Methods Clin Dev, 2017;5(0):241-258.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: J Huang, A Khan, BC Au, DL Barber, L López-Vásq, NL Prokopishy, M Boutin, M Rothe, JW Rip, M Abaoui, MS Nagree, S Dworski, A Schambach, A Keating, ML West, J Klassen, PV Turner, S Sirrs, CA Rupar, C Auray-Blai, R Foley, JA Medin
Mol Ther Methods Clin Dev, 2017;5(0):241-258.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Establishment of an induced pluripotent stem cell (iPSC) line from a 9-year old male with autism spectrum disorder (ASD)
Authors: E Varga, C Nemes, I Bock, Z Táncos, S Berzsenyi, G Lévay, V Román, J Kobolák, A Dinnyés
Stem Cell Res, 2017;21(0):19-22.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: E Varga, C Nemes, I Bock, Z Táncos, S Berzsenyi, G Lévay, V Román, J Kobolák, A Dinnyés
Stem Cell Res, 2017;21(0):19-22.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Functional IL-33 receptors are expressed in early progenitor stages of allergy-related granulocytes
Immunology, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Immunology, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells
Nature, 2016;532(7600):508-11.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Nature, 2016;532(7600):508-11.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Robust reprogramming of Ataxia-Telangiectasia patient and carrier erythroid cells to induced pluripotent stem cells
Stem Cell Res, 2016;17(2):296-305.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Stem Cell Res, 2016;17(2):296-305.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway
Cell Biosci, 2016;6(1):50.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Cell Biosci, 2016;6(1):50.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Effect of high-dose plerixafor on CD34+ cells mobilization in healthy stem-cell donors: results of a randomized crossover trial
Haematologica, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Haematologica, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Identifying residues that determine SCF molecular-level interactions through a combination of experimental and in silico analyses
J. Mol. Biol., 2016;0(0):.
Species: Human
Sample Type: Recombinant Protein
Application: Bioassay
J. Mol. Biol., 2016;0(0):.
Species: Human
Sample Type: Recombinant Protein
Application: Bioassay
Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease
JCI Insight, 2016;1(20):e87446.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
JCI Insight, 2016;1(20):e87446.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Decitabine enhances anti-CD33 monoclonal antibody BI 836858-mediated natural killer ADCC against AML blasts
Blood, 2016;127(23):2879-89.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Blood, 2016;127(23):2879-89.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML
Mol Ther Methods Clin Dev, 2016;3(0):16074.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Mol Ther Methods Clin Dev, 2016;3(0):16074.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer.
Authors: Hermanson D, Bendzick L, Pribyl L, McCullar V, Vogel R, Miller J, Geller M, Kaufman D
Stem Cells, 2016;34(1):93-101.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Hermanson D, Bendzick L, Pribyl L, McCullar V, Vogel R, Miller J, Geller M, Kaufman D
Stem Cells, 2016;34(1):93-101.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Efficient regeneration of Human V?24(+) invariant NKT cells and their anti-tumor activity in vivo
Stem Cells, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Stem Cells, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML).
Authors: Jiang X, Lim C, Li Z, Lee P, Yatim S, Guan P, Li J, Zhou J, Pan J, Chng W, Chai C, Yu Q
PLoS ONE, 2015;10(4):e0122983.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Jiang X, Lim C, Li Z, Lee P, Yatim S, Guan P, Li J, Zhou J, Pan J, Chng W, Chai C, Yu Q
PLoS ONE, 2015;10(4):e0122983.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Reversible lineage-specific priming of human embryonic stem cells can be exploited to optimize the yield of differentiated cells.
Authors: Lee J, Graham M, Collins T, Lee J, Hong S, McNicol A, Shapovalova Z, Bhatia M
Stem Cells, 2015;33(4):1142-52.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Lee J, Graham M, Collins T, Lee J, Hong S, McNicol A, Shapovalova Z, Bhatia M
Stem Cells, 2015;33(4):1142-52.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Small-molecule inhibitor of glycogen synthase kinase 3beta 6-Bromoindirubin-3-oxime inhibits hematopoietic regeneration in stem cell recipient mice.
Authors: Shen S, Xu N, Klamer G, Ko K, Khoo M, Ma D, Moore J, O'Brien T, Dolnikov A
Stem Cells Dev, 2015;24(6):724-36.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Shen S, Xu N, Klamer G, Ko K, Khoo M, Ma D, Moore J, O'Brien T, Dolnikov A
Stem Cells Dev, 2015;24(6):724-36.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Distinct mechanisms of inadequate erythropoiesis induced by tumor necrosis factor alpha or malarial pigment.
Authors: Lamikanra A, Merryweather-Clarke A, Tipping A, Roberts D
PLoS ONE, 2015;10(3):e0119836.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Lamikanra A, Merryweather-Clarke A, Tipping A, Roberts D
PLoS ONE, 2015;10(3):e0119836.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues.
Authors: Patterson, Scott D, Rossi, John M, Paweletz, Katherin, Fitzpatrick, V Dan, Begley, C Glenn, Busse, Leigh, Elliott, Steve, McCaffery, Ian
PLoS ONE, 2015;10(3):e0122149.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Patterson, Scott D, Rossi, John M, Paweletz, Katherin, Fitzpatrick, V Dan, Begley, C Glenn, Busse, Leigh, Elliott, Steve, McCaffery, Ian
PLoS ONE, 2015;10(3):e0122149.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Transcriptome analysis of Kaposi's sarcoma-associated herpesvirus during de novo primary infection of human B and endothelial cells.
Authors: Purushothaman P, Thakker S, Verma S
J Virol, 2015;89(6):3093-111.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Purushothaman P, Thakker S, Verma S
J Virol, 2015;89(6):3093-111.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Human umbilical cord blood mesenchymal stem cell-derived PGE2 and TGF-beta1 alleviate atopic dermatitis by reducing mast cell degranulation.
Authors: Kim H, Yun J, Shin T, Lee S, Lee B, Yu K, Seo Y, Lee S, Kang T, Choi S, Seo K, Kang K
Stem Cells, 2015;33(4):1254-66.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Kim H, Yun J, Shin T, Lee S, Lee B, Yu K, Seo Y, Lee S, Kang T, Choi S, Seo K, Kang K
Stem Cells, 2015;33(4):1254-66.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system.
Authors: Song B, Fan Y, He W, Zhu D, Niu X, Wang D, Ou Z, Luo M, Sun X
Stem Cells Dev, 2015;24(9):1053-65.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Song B, Fan Y, He W, Zhu D, Niu X, Wang D, Ou Z, Luo M, Sun X
Stem Cells Dev, 2015;24(9):1053-65.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
GSK3beta inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells.
Authors: Kitajima K, Nakajima M, Kanokoda M, Kyba M, Dandapat A, Tolar J, Saito M, Toyoda M, Umezawa A, Hara T
Exp Hematol, 2015;44(1):68-74.e10.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Kitajima K, Nakajima M, Kanokoda M, Kyba M, Dandapat A, Tolar J, Saito M, Toyoda M, Umezawa A, Hara T
Exp Hematol, 2015;44(1):68-74.e10.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Regulated apoptosis of genetically modified hematopoietic stem and progenitor cells via an inducible caspase-9 suicide gene in rhesus macaques.
Authors: Barese C, Felizardo T, Sellers S, Keyvanfar K, Di Stasi A, Metzger M, Krouse A, Donahue R, Spencer D, Dunbar C
Stem Cells, 2015;33(1):91-100.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Type: Whole Cells
Application: Bioassay
Authors: Barese C, Felizardo T, Sellers S, Keyvanfar K, Di Stasi A, Metzger M, Krouse A, Donahue R, Spencer D, Dunbar C
Stem Cells, 2015;33(1):91-100.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Type: Whole Cells
Application: Bioassay
Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment.
Authors: Horwitz, Mitchell, Chao, Nelson J, Rizzieri, David A, Long, Gwynn D, Sullivan, Keith M, Gasparetto, Cristina, Chute, John P, Morris, Ashley, McDonald, Carolyn, Waters-Pick, Barbara, Stiff, Patrick, Wease, Steven, Peled, Amnon, Snyder, David, Cohen, Einat Ga, Shoham, Hadas, Landau, Efrat, Friend, Etty, Peleg, Iddo, Aschengrau, Dorit, Yackoubov, Dima, Kurtzberg, Joanne, Peled, Tony
J Clin Invest, 2014;124(7):3121-8.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Horwitz, Mitchell, Chao, Nelson J, Rizzieri, David A, Long, Gwynn D, Sullivan, Keith M, Gasparetto, Cristina, Chute, John P, Morris, Ashley, McDonald, Carolyn, Waters-Pick, Barbara, Stiff, Patrick, Wease, Steven, Peled, Amnon, Snyder, David, Cohen, Einat Ga, Shoham, Hadas, Landau, Efrat, Friend, Etty, Peleg, Iddo, Aschengrau, Dorit, Yackoubov, Dima, Kurtzberg, Joanne, Peled, Tony
J Clin Invest, 2014;124(7):3121-8.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia.
Authors: Williams M, Yousafzai Y, Cox C, Blair A, Carmody R, Sai S, Chapman K, McAndrew R, Thomas A, Spence A, Gibson B, Graham G, Halsey C
Blood, 2014;123(20):3116-27.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Williams M, Yousafzai Y, Cox C, Blair A, Carmody R, Sai S, Chapman K, McAndrew R, Thomas A, Spence A, Gibson B, Graham G, Halsey C
Blood, 2014;123(20):3116-27.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Gene transfer properties and structural modeling of human stem cell-derived AAV.
Authors: Smith, Laura J, Ul-Hasan, Taihra, Carvaines, Sarah K, Van Vliet, Kim, Yang, Ethel, Wong, Kamehame, Agbandje-McKenna, Mavis, Chatterjee, Saswati
Mol Ther, 2014;22(9):1625-34.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Smith, Laura J, Ul-Hasan, Taihra, Carvaines, Sarah K, Van Vliet, Kim, Yang, Ethel, Wong, Kamehame, Agbandje-McKenna, Mavis, Chatterjee, Saswati
Mol Ther, 2014;22(9):1625-34.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Quantitative measurement of alterations in DNA damage repair (DDR) pathways using single cell network profiling (SCNP).
Authors: Rosen, David B, Leung, Ling Y, Louie, Brent, Cordeiro, James A, Conroy, Andrew, Shapira, Iuliana, Fields, Scott Z, Cesano, Alessand, Hawtin, Rachael
J Transl Med, 2014;12(0):184.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Rosen, David B, Leung, Ling Y, Louie, Brent, Cordeiro, James A, Conroy, Andrew, Shapira, Iuliana, Fields, Scott Z, Cesano, Alessand, Hawtin, Rachael
J Transl Med, 2014;12(0):184.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells.
Authors: Kamat V, Paluru P, Myint M, French D, Gadue P, Diamond S
Stem Cells, 2014;32(5):1337-46.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Kamat V, Paluru P, Myint M, French D, Gadue P, Diamond S
Stem Cells, 2014;32(5):1337-46.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Molecular and stimulus-response profiles illustrate heterogeneity between peripheral and cord blood-derived human mast cells.
Authors: Jensen B, Frandsen P, Raaby E, Schiotz P, Skov P, Poulsen L
J Leukoc Biol, 2014;95(6):893-901.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Jensen B, Frandsen P, Raaby E, Schiotz P, Skov P, Poulsen L
J Leukoc Biol, 2014;95(6):893-901.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells.
Authors: Wu C, Li B, Lu R, Koelle S, Yang Y, Jares A, Krouse A, Metzger M, Liang F, Lore K, Wu C, Donahue R, Chen I, Weissman I, Dunbar C
Cell Stem Cell, 2014;14(4):486-99.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Type: Whole Cells
Application: Bioassay
Authors: Wu C, Li B, Lu R, Koelle S, Yang Y, Jares A, Krouse A, Metzger M, Liang F, Lore K, Wu C, Donahue R, Chen I, Weissman I, Dunbar C
Cell Stem Cell, 2014;14(4):486-99.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Type: Whole Cells
Application: Bioassay
Long-term reproducible expression in human fetal liver hematopoietic stem cells with a UCOE-based lentiviral vector.
Authors: Dighe N, Khoury M, Mattar C, Chong M, Choolani M, Chen J, Antoniou M, Chan J
PLoS ONE, 2014;9(8):e104805.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Dighe N, Khoury M, Mattar C, Chong M, Choolani M, Chen J, Antoniou M, Chan J
PLoS ONE, 2014;9(8):e104805.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation.
Authors: Klimenkova O, Ellerbeck W, Klimiankou M, Unalan M, Kandabarau S, Gigina A, Hussein K, Zeidler C, Welte K, Skokowa J
Blood, 2014;123(8):1239-49.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Klimenkova O, Ellerbeck W, Klimiankou M, Unalan M, Kandabarau S, Gigina A, Hussein K, Zeidler C, Welte K, Skokowa J
Blood, 2014;123(8):1239-49.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Evaluation of engraftment and immunological tolerance after reduced intensity conditioning in a rhesus hematopoietic stem cell gene therapy model.
Authors: Uchida N, Weitzel R, Evans M, Green R, Bonifacino A, Krouse A, Metzger M, Hsieh M, Donahue R, Tisdale J
Gene Ther, 2014;21(2):148-57.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Type: Whole Cells
Application: Bioassay
Authors: Uchida N, Weitzel R, Evans M, Green R, Bonifacino A, Krouse A, Metzger M, Hsieh M, Donahue R, Tisdale J
Gene Ther, 2014;21(2):148-57.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Type: Whole Cells
Application: Bioassay
The adult livers of immunodeficient mice support human hematopoiesis: evidence for a hepatic mast cell population that develops early in human ontogeny.
Authors: Muench M, Beyer A, Fomin M, Thakker R, Mulvaney U, Nakamura M, Suemizu H, Barcena A
PLoS ONE, 2014;9(5):e97312.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Muench M, Beyer A, Fomin M, Thakker R, Mulvaney U, Nakamura M, Suemizu H, Barcena A
PLoS ONE, 2014;9(5):e97312.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa.
Authors: Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, Keene D, Liu L, Osborn M, Lund T, Blazar B, Wagner J
J Invest Dermatol, 2014;134(5):1246-54.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, Keene D, Liu L, Osborn M, Lund T, Blazar B, Wagner J
J Invest Dermatol, 2014;134(5):1246-54.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling.
Authors: Csaszar, Elizabet, Wang, Weijia, Usenko, Tatiana, Qiao, Wenlian, Delaney, Colleen, Bernstein, Irwin D, Zandstra, Peter W
Blood, 2014;123(5):650-8.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Csaszar, Elizabet, Wang, Weijia, Usenko, Tatiana, Qiao, Wenlian, Delaney, Colleen, Bernstein, Irwin D, Zandstra, Peter W
Blood, 2014;123(5):650-8.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value.
Authors: Vannucchi, A M, Rotunno, G, Bartalucci, N, Raugei, G, Carrai, V, Balliu, M, Mannarelli, C, Pacilli, A, Calabresi, L, Fjerza, R, Pieri, L, Bosi, A, Manfredini, R, Guglielmelli, P
Leukemia, 2014;28(9):1811-8.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Vannucchi, A M, Rotunno, G, Bartalucci, N, Raugei, G, Carrai, V, Balliu, M, Mannarelli, C, Pacilli, A, Calabresi, L, Fjerza, R, Pieri, L, Bosi, A, Manfredini, R, Guglielmelli, P
Leukemia, 2014;28(9):1811-8.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
BCR-ABL-induced deregulation of the IL-33/ST2 pathway in CD34+ progenitors from chronic myeloid leukemia patients.
Authors: Levescot A, Flamant S, Basbous S, Jacomet F, Feraud O, Anne Bourgeois E, Bonnet M, Giraud C, Roy L, Barra A, Chomel J, Turhan A, Guilhot F, Girard J, Gombert J, Herbelin A
Cancer Res, 2014;74(10):2669-76.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Levescot A, Flamant S, Basbous S, Jacomet F, Feraud O, Anne Bourgeois E, Bonnet M, Giraud C, Roy L, Barra A, Chomel J, Turhan A, Guilhot F, Girard J, Gombert J, Herbelin A
Cancer Res, 2014;74(10):2669-76.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Epigenetic reprogramming induces the expansion of cord blood stem cells.
Authors: Chaurasia P, Gajzer D, Schaniel C, D'Souza S, Hoffman R
J Clin Invest, 2014;124(6):2378-95.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Chaurasia P, Gajzer D, Schaniel C, D'Souza S, Hoffman R
J Clin Invest, 2014;124(6):2378-95.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.
Authors: Reynolds, C, Roderick, J E, LaBelle, J L, Bird, G, Mathieu, R, Bodaar, K, Colon, D, Pyati, U, Stevenson, K E, Qi, J, Harris, M, Silverman, L B, Sallan, S E, Bradner, J E, Neuberg, D S, Look, A T, Walensky, L D, Kelliher, M A, Gutierrez, A
Leukemia, 2014;28(9):1819-27.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Reynolds, C, Roderick, J E, LaBelle, J L, Bird, G, Mathieu, R, Bodaar, K, Colon, D, Pyati, U, Stevenson, K E, Qi, J, Harris, M, Silverman, L B, Sallan, S E, Bradner, J E, Neuberg, D S, Look, A T, Walensky, L D, Kelliher, M A, Gutierrez, A
Leukemia, 2014;28(9):1819-27.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Gene profiling reveals association between altered Wnt signaling and loss of T-cell potential with age in human hematopoietic stem cells.
Authors: Khoo M, Carlin S, Lutherborrow M, Jayaswal V, Ma D, Moore J
Aging Cell, 2014;13(4):744-54.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Khoo M, Carlin S, Lutherborrow M, Jayaswal V, Ma D, Moore J
Aging Cell, 2014;13(4):744-54.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells.
Authors: Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita K, Koike T, Harimoto K, Dohda T, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K
Cell Stem Cell, 2014;14(4):535-48.
Authors: Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita K, Koike T, Harimoto K, Dohda T, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K
Cell Stem Cell, 2014;14(4):535-48.
Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis.
Authors: Morishima, Tatsuya, Watanabe, Ken-ichi, Niwa, Akira, Hirai, Hideyo, Saida, Satoshi, Tanaka, Takayuki, Kato, Itaru, Umeda, Katsutsu, Hiramatsu, Hidefumi, Saito, Megumu K, Matsubara, Kousaku, Adachi, Souichi, Kobayashi, Masao, Nakahata, Tatsutos, Heike, Toshio
Haematologica, 2014;99(1):19-27.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Morishima, Tatsuya, Watanabe, Ken-ichi, Niwa, Akira, Hirai, Hideyo, Saida, Satoshi, Tanaka, Takayuki, Kato, Itaru, Umeda, Katsutsu, Hiramatsu, Hidefumi, Saito, Megumu K, Matsubara, Kousaku, Adachi, Souichi, Kobayashi, Masao, Nakahata, Tatsutos, Heike, Toshio
Haematologica, 2014;99(1):19-27.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies.
Authors: Kazuki, Yasuhiro, Yakura, Yuwna, Abe, Satoshi, Osaki, Mitsuhik, Kajitani, Naoyo, Kazuki, Kanako, Takehara, Shoko, Honma, Kazuhisa, Suemori, Hirofumi, Yamazaki, Satoshi, Sakuma, Tetsushi, Toki, Tsutomu, Shimizu, Ritsuko, Nakauchi, Hiromits, Yamamoto, Takashi, Oshimura, Mitsuo
Sci Rep, 2014;4(0):6136.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Kazuki, Yasuhiro, Yakura, Yuwna, Abe, Satoshi, Osaki, Mitsuhik, Kajitani, Naoyo, Kazuki, Kanako, Takehara, Shoko, Honma, Kazuhisa, Suemori, Hirofumi, Yamazaki, Satoshi, Sakuma, Tetsushi, Toki, Tsutomu, Shimizu, Ritsuko, Nakauchi, Hiromits, Yamamoto, Takashi, Oshimura, Mitsuo
Sci Rep, 2014;4(0):6136.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity.
Authors: Jitkova, Yulia, Gronda, Marcela, Hurren, Rose, Wang, Xiaoming, Goard, Carolyn, Jhas, Bozhena, Schimmer, Aaron D
PLoS ONE, 2014;9(5):e95281.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Jitkova, Yulia, Gronda, Marcela, Hurren, Rose, Wang, Xiaoming, Goard, Carolyn, Jhas, Bozhena, Schimmer, Aaron D
PLoS ONE, 2014;9(5):e95281.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The MAPK pathway functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma.
Authors: Todd J, Scurr L, Becker T, Kefford R, Rizos H
Oncogene, 2014;33(2):236-45.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Todd J, Scurr L, Becker T, Kefford R, Rizos H
Oncogene, 2014;33(2):236-45.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Platelet-derived growth factor-BB activates calcium/calmodulin-dependent and -independent mechanisms that mediate Akt phosphorylation in the neurofibromin-deficient human Schwann cell line ST88-14.
Authors: Farrer R, Farrer J, DeVries G
J Biol Chem, 2013;288(16):11066-73.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Farrer R, Farrer J, DeVries G
J Biol Chem, 2013;288(16):11066-73.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions.
Authors: Smith A, Bowers S, Stratman A, Davis G
PLoS ONE, 2013;8(12):e85147.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Smith A, Bowers S, Stratman A, Davis G
PLoS ONE, 2013;8(12):e85147.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
beta-Globin sleeping beauty transposon reduces red blood cell sickling in a patient-derived CD34(+)-based in vitro model.
Authors: Sjeklocha L, Wong P, Belcher J, Vercellotti G, Steer C
PLoS ONE, 2013;8(11):e80403.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Sjeklocha L, Wong P, Belcher J, Vercellotti G, Steer C
PLoS ONE, 2013;8(11):e80403.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells.
Authors: Giannoni F, Hardee C, Wherley J, Gschweng E, Senadheera S, Kaufman M, Chan R, Bahner I, Gersuk V, Wang X, Gjertson D, Baltimore D, Witte O, Economou J, Ribas A, Kohn D
Mol Ther, 2013;21(5):1044-54.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Giannoni F, Hardee C, Wherley J, Gschweng E, Senadheera S, Kaufman M, Chan R, Bahner I, Gersuk V, Wang X, Gjertson D, Baltimore D, Witte O, Economou J, Ribas A, Kohn D
Mol Ther, 2013;21(5):1044-54.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.
Authors: Doulatov S, Vo L, Chou S, Kim P, Arora N, Li H, Hadland B, Bernstein I, Collins J, Zon L, Daley G
Cell Stem Cell, 2013;13(4):459-70.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Doulatov S, Vo L, Chou S, Kim P, Arora N, Li H, Hadland B, Bernstein I, Collins J, Zon L, Daley G
Cell Stem Cell, 2013;13(4):459-70.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Epigenetic regulation of NANOG by miR-302 cluster-MBD2 completes induced pluripotent stem cell reprogramming.
Authors: Lee M, Prasain N, Chae H, Kim Y, Mantel C, Yoder M, Broxmeyer H
Stem Cells, 2013;31(4):666-81.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Authors: Lee M, Prasain N, Chae H, Kim Y, Mantel C, Yoder M, Broxmeyer H
Stem Cells, 2013;31(4):666-81.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Gene expression patterns of hemizygous and heterozygous KIT mutations suggest distinct oncogenic pathways: a study in NIH3T3 cell lines and GIST samples.
Authors: Bachet J, Tabone-Eglinger S, Dessaux S, Besse A, Brahimi-Adouane S, Emile J, Blay J, Alberti L
PLoS ONE, 2013;8(4):e61103.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Authors: Bachet J, Tabone-Eglinger S, Dessaux S, Besse A, Brahimi-Adouane S, Emile J, Blay J, Alberti L
PLoS ONE, 2013;8(4):e61103.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
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