抗LRP5/6, mAb (rec.) (Heldy-1-4)抗体 | Anti-LRP5/6, mAb (rec.) (Heldy-1-4) antibody | Adipogen
掲載日情報：2017/10/30 現在Webページ番号：205434
Adipogen社の抗LRP5/6, mAb (rec.) (Heldy-1-4)抗体(Anti-LRP5/6, mAb (rec.) (Heldy-1-4) antibody)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2025年05月01日 00時00分現在]
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Anti-LRP5/6, mAb (rec.) (Heldy-1-4) |
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[在庫・価格 ：2025年05月01日 00時00分現在]
Anti-LRP5/6, mAb (rec.) (Heldy-1-4)
文献数： 0
- 商品コード：AG-27B-0019-C100
- メーカー：KOM
- 包装：100μg
- 価格：¥101,000
- 在庫：無(未発注)
- 納期：2週間程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | 純度：>95% (SDS-PAGE) 別名：Low-density Lipoprotein Receptor-related Protein 5，LRP-5，Low-density Lipoprotein Receptor-related Protein 6，LRP-6 クローン：Heldy-1-4 Protein Accession No： Q91VN0 O88572 |
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| 法規制等 | |||
| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | 免疫動物 | Human | |
| 交差性 | Human/Mouse | 適用 | FCM |
| 標識 | Unlabeled | 性状 | |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Recombinant | フォーマット | |
| 掲載カタログ |
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| 製品記事 | 組換えモノクローナル抗体「RecMAbs」 |
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| 関連記事 | ファージディスプレイ技術による組換え抗体（AdipoGen Life Sciences社） |
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製品説明
Wnt/β-catenin signaling acts as a regulator of tissue development and homeostasis. Wnt ligands bind to a member of the Frizzled family of seven-transmembrane proteins and to either highly homologous low-density lipoprotein related receptors 5 (LRP5) or LRP6. Low-density lipoprotein receptor-related protein 6 (LRP6) is a member of the low-density lipoprotein receptor (LDLR) family. LRP5 and LRP6 are expressed in most human tissues and is composed of three distinctive cell-surface protein domains, including (1) LDL receptor (LDLR) type A repeats; (2) an epidermal growth factor (EGF)-like domain; and (3) a YWTD (Tyr-Trp-Thr-Asp)-type β propeller domain. LRP6 is inhibited by the Dickkopf protein Dkk1 bound to their partners Kremen. Sclerotin also acts as an inhibitor of LRP5/6 through LRP4. LRP6 is involved in cell differentiation, proliferation and migration during embryonic development and in the pathogenesis of different cancer types. LRP6 plays a major role in metabolic regulation, specifically in the nutrient-sensing pathway. Patients carrying an LRP6 mutation exhibit high serum LDL cholesterol and triglycerides, hypertension, high fasting blood glucose levels, a prevalence of diabetes and low bone density. LRP6 mutations have also been associated with diseases such as Alzheimer's and degenerative joint diseases. LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density and plays a role in osteoporosis. LRP5 is aso involved in vitreoretinopathy.
追加しました。
製品情報
| Clone | Heldy-1-4 |
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| Isotype | Human IgG2λ. |
| Source/Host | HEK 293 cells |
| Immunogen/Antigen | Recombinant mouse LRP6. |
| Application | Flow Cytometry: 1/100 dilution |
| Crossreactivity | Human, Mouse |
| Specificity | Recognizes human and mouse LRP5 & LRP6. |
| Purity | ≥95% (SDS-PAGE) |
| Purity Detail | Protein A-affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. In PBS containing 10% glycerol. |
| Other Product Data | anti-LRP5/6 (human), mAb (rec.) (Heldy-1-4) is composed of human variable regions (VH and VL) (λ-chain) of immunoglobulin fused to the human lgG2 Fc domain. |
| Product Type | Recombinant Antibody |
追加しました。
画像
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Detection of endogenous mouse LRP5/6 using anti-LRP5/6, mAb (rec.) (Heldy-1-4) (Prod. No. AG-27B-0019). Method: B16 melanoma mouse cells were stained with anti-LRP5/6, mAb (rec.) (Heldy-1-4) (blue and red lines) (1/100 in PBS + 2% FCS) or with the secondary antibody alone as control (gray area) for 1h at 4°C. The staining was revealed with a secondary anti-human IgG-PE (1/200) and then analyzed by flow cytometry. The blue and red lines represent two different lots of anti-LRP5/6, mAb (rec.) (Heldy-1-4). Picture courtesy of Prof. Werner Held lab, Ludwig Institute for Cancer Research, Lausanne, Switzerland. |
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Detection of overexpressed human LRP6 using anti-LRP5/6, mAb (rec.) (Heldy-1-4) (Prod. No. AG-27B-0019). Method: HEK293 cells transfected (green line) or mock transfected (black line) with a dicistronic plasmid encoding for human LRP6 and GFP, were stained with anti-LRP5/6, mAb (rec.) (Heldy-1-4) (1/100 in PBS + 2% FCS) or with the secondary antibody alone as control (gray area) for 1h at 4°C. The staining was revealed with an anti-human IgG PE (1/200) and then analyzed by flow cytometry. Picture courtesy of Prof. Werner Held lab, Ludwig Institute for Cancer Research, Lausanne, Switzerland. |
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Structure of the recombinant antibody anti-LRP5/6, mAb (rec.) (Heldy-1-4) (Prod. No. AG-27B-0019). The single chain variable human fragment (ScFv) selected by antibody phage display technology and specific to the antigen of interest is fused to a human IgG2 Fc region. |
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