抗Polyglutamylation Modification, mAb (GT335) (Biotin)抗体 | Anti-Polyglutamylation Modification, mAb (GT335) (Biotin) antibody | Adipogen
掲載日情報：2017/10/30 現在Webページ番号：205100
Adipogen社の抗Polyglutamylation Modification, mAb (GT335) (Biotin)抗体(Anti-Polyglutamylation Modification, mAb (GT335) (Biotin) antibody)です。
※本製品は研究用です。研究用以外には使用できません。
[在庫・価格 ：2024年05月04日 14時55分現在]
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[在庫・価格 ：2024年05月04日 14時55分現在]
Anti-Polyglutamylation Modification, mAb (GT335) (Biotin)
文献数： 0
- 商品コード：AG-20B-0020B-C100
- メーカー：KOM
- 包装：100μg
- 価格：¥111,000
- 在庫：無(未発注)
- 納期：2週間程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
Recognizes most forms of polyglutamylated tubulin( - and -tubulin), independent of the length of theglutamate side chains. No specificity to particular tubulinisoforms nor to tubulin from particular speciesare observed. Detects also other (poly)glutamylatedproteins. Since no consensus modification site isknown for protein (poly)glutamylation, the detectionis not sequence-specific. However, an acidic environmentof the modification site is required.。 別名：Polyglutamylated Tubulin，Glutamylated Tubulin，Postranslational Protein Glutamylation クローン：GT335 |
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| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | 免疫動物 | Mouse | |
| 交差性 | All | 適用 | IC,IHC,IP,Western Blot |
| 標識 | Biotin | 性状 | |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Monoclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 |
Anti-Polyglutamylation Modification Antibody チューブリン翻訳後修飾（PTM）関連抗体 細胞周期・微小管研究用製品特集 |
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追加しました。
製品説明
Polyglutamylation is a post-translational modification in which glutamate side chains of variable lengths are formed on the modified protein. It is evolutionarily conserved and the most prominent substrate is tubulin, the microtubule (MT) building block. Polyglutamylation has been proposed to be involved in the functional adaptation of MTs, as it occurs within the carboxy-terminal tubulin tails that participate directly in the binding of many structural and motor MT-associated proteins. The recent identification of new substrates of polyglutamylation indicates that this post-translational modification could be a potential regulator of diverse cellular processes and be involved in cell cycle and cell proliferation.
追加しました。
製品情報
| Clone | GT335 |
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| Isotype | Mouse IgG1κ |
| Source/Host | Purified from concentrated hybridoma tissue culture supernatant. |
| Immunogen/Antigen | Octapeptide EGEGE*EEG, modified by the addition of two glutamyl units onto the fifth E (indicated by an asterisk). |
| Label/Conjugates | Biotin |
| Application |
Immunocytochemistry: (1:2000) Immunoprecipitation Western Blot: (1:4000) Optimal conditions must be determined individually for each application. |
| Crossreactivity | All |
| Specificity | Recognizes the posttranslational modification (poly)glutamylation on proteins. Reacts with polyglutamylated α- and β-tubulin. |
| Purity | ≥95% (SDS-PAGE) |
| Purity Detail | Protein G-affinity purified. |
| Concentration | 1mg/ml |
| Formulation | Liquid. In PBS containing 0.02% sodium azide. |
| Other Product Data | Recognizes most forms of polyglutamylated tubulin (α- and β-tubulin), independent of the length of the glutamate side chains. No specificity to particular tubulin isoforms nor to tubulin from particular species are observed. Detects also other (poly)glutamylated proteins. Since no consensus modification site is known for protein (poly)glutamylation, the detection is not sequence-specific. However, an acidic environment of the modification site is required. The use of the antibody at too high concentrations obscures its specificity in immunofluorescence. |
| Product Type | Monoclonal Antibody |
追加しました。
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