抗Human TGF-beta RIII抗体(Anti-Human TGF-beta RIII antibody)
掲載日情報：2021/01/28 現在Webページ番号：199450
Human TGF-beta RIIIに対する抗体(Anti-Human TGF-beta RIII )です。
※ 本製品は研究用です。研究用以外には使用できません。
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価格
[在庫・価格 ：2025年04月26日 20時35分現在]
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Anti-Human TGF-beta RIII MAb (Clone 31308) |
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Anti-Human TGF-beta RIII MAb (Clone 31308) |
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[在庫・価格 ：2025年04月26日 20時35分現在]
Anti-Human TGF-beta RIII MAb (Clone 31308)
文献数： 0
- 商品コード：MAB2421
- メーカー：RSD
- 包装：500μg
- 価格：¥122,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | マッチドペア：Human TGF-β RIII サンドイッチELISAの補足用抗体として利用可能，検出用抗体として#BAF242，スタンダードとして#242-R3-100を用いる。 別名：betaglycan クローン：31308 Genbank No： 7049 Protein Accession No： AAA67061 |
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| 保存条件 | 法規備考 | ||||||
| 抗原種 | 免疫動物 | Mouse | |||||
| 交差性 | Human | 適用 | ELISA | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
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| 製品記事 | |||||||
| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Anti-Human TGF-beta RIII MAb (Clone 31308)
文献数： 0
- 商品コード：MAB2421-SP
- メーカー：RSD
- 包装：25μg
- 価格：¥30,000
- 在庫：無(未発注)
- 納期：2～3週間 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 | ※受注発注品。形状：溶液または凍結乾燥 別名：betaglycan クローン：31308 Genbank No： 7049 Protein Accession No： AAA67061 |
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| 別包装品 | 別包装品あり | ||||||
| 法規制等 | |||||||
| 保存条件 | 法規備考 | ||||||
| 抗原種 | 免疫動物 | Mouse | |||||
| 交差性 | Human | 適用 | ELISA | ||||
| 標識 | Unlabeled | 性状 | Protein A/G Affinity Purified | ||||
| 吸収処理 | クラス | IgG | |||||
| クロナリティ | Monoclonal | フォーマット | |||||
| 掲載カタログ |
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| 製品記事 | 使いっきり抗体 |
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| 関連記事 | R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human |
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| Label | Unconjugated |
| Immunogen | Murine myeloma cell line, NS0-derived recombinant human TGF-beta RIIIGly21-Asp781Accession # AAA67061 |
| Source | Monoclonal Mouse IgG1 Clone # 31308 |
| Purification | Protein A or G purified from hybridoma culture supernatant |
| Specificity | Detects human TGF-beta RIII in ELISAs. In sandwich immunoassays, no cross-reactivity or interference with recombinant human (rh) TGF-beta RI, RII, RIIb, recombinant mouse (rm) TGF-beta RIII, rhTGF-beta 1, beta 1.2, beta 2, beta 3, rhLatent TGF-beta 1, or rhLAP is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Human TGF-beta RIII Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 0.5-2.0 µg/mL | Human TGF‑ beta RIII Antibody (Catalog #MAB2421 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-.04 µg/mL | Human TGF‑ beta RIII Biotinylated Antibody (Catalog #BAF242 ) |
| ELISA Standard | Recombinant Human TGF-beta RIII Protein (Catalog #242-R3 ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.5 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: TGF-beta RIII | Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70-85 kDa), and Type III (250-350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction. The Type III receptor binds TGF-beta 2 with the highest affinity. Other TGF-beta isoforms also bind the Type III receptor, but with lower affinities. Cellular responsiveness to TGF-beta 2 appears to be dependent on the presence of the Type III receptor which can interact with the signaling receptor complex. In addition to the transmembrane Type III receptor, a soluble form of the receptor is secreted by some cell types. The physiological role of this soluble receptor remains to be determined. The recombinant TGF-beta soluble receptor Type III binds the TGF-beta isoforms differentially in solution and exhibits TGF-beta antagonistic activities in vitro. |
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| Long Name: | Transforming Growth Factor beta Receptor III | |
| Entrez Gene IDs: | 7049 (Human); 21814 (Mouse); 29610 (Rat) | |
| Alternate Names: | betaglycan proteoglycan; Betaglycan; BGCAN; TBRIII; TGF-beta receptor type 3; TGF-beta receptor type III; TGF-beta RIII; TGFbetaRIII; TGFBR3; TGF-bRIII; TGFR-3; Transforming growth factor beta receptor III; transforming growth factor beta receptor type 3; transforming growth factor, beta receptor III (betaglycan, 300kDa); transforming growth factor, beta receptor III | |
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Related Research Areas
| Airway Inflammation and Remodeling |
| Cytokines and Receptors in Allergy and Asthma |
| Cytokines and Receptors in Angiogenesis |
| Proteoglycans |
| T Cell Cytokine Signaling |
| TGF-beta Family |
| TGF-beta Superfamily |
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Related Product & Information
| Background | TGF-beta RIII |
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| background_content | Background: TGF-beta RIII Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70-85 kDa), and Type III (250-350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction. The Type III receptor binds TGF-beta 2 with the highest affinity. Other TGF-beta isoforms also bind the Type III receptor, but with lower affinities. Cellular responsiveness to TGF-beta 2 appears to be dependent on the presence of the Type III receptor which can interact with the signaling receptor complex. In addition to the transmembrane Type III receptor, a soluble form of the receptor is secreted by some cell types. The physiological role of this soluble receptor remains to be determined. The recombinant TGF-beta soluble receptor Type III binds the TGF-beta isoforms differentially in solution and exhibits TGF-beta antagonistic activities in vitro. |
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