抗Human FOLR1 Biotinylated抗体(Anti-Human FOLR1 Biotinylated antibody)
掲載日情報：2021/01/28 現在Webページ番号：199430
Human FOLR1 Biotinylatedに対する抗体(Anti-Human FOLR1 Biotinylated )です。
※ 本製品は研究用です。研究用以外には使用できません。
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- 価格
- Product Details
- Applications and Data
- References
- Related Research Areas
- Related Product & Information
- Citations
価格
[在庫・価格 ：2024年05月18日 00時00分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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Anti-Human FOLR1 Biotinylated Affinity Purified PAb (50 UG) |
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[在庫・価格 ：2024年05月18日 00時00分現在]
※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
Anti-Human FOLR1 Biotinylated Affinity Purified PAb (50 UG)
文献数： 3
- 商品コード：BAF5646
- メーカー：RSD
- 包装：50μg
- 価格：¥118,000
- 在庫：無(未発注)
- 納期：10日程度 ※※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。
- 法規制等：
| 説明文 |
マッチドペア：Human FOLR1 サンドイッチELISAの検出用抗体として利用可能，補足用抗体として#MAB5646，スタンダードとして#5646-FR-050を用いる。 別名：Adult folate-binding protein Genbank No： 2348 Protein Accession No： P15328 |
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| 保存条件 | -20℃ | 法規備考 | |
| 抗原種 | Human | 免疫動物 | Goat |
| 交差性 | Human | 適用 | ELISA,Western Blot |
| 標識 | Biotin | 性状 | Antigen Affinity Purified |
| 吸収処理 | クラス | IgG | |
| クロナリティ | Polyclonal | フォーマット | |
| 掲載カタログ |
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| 製品記事 |
Human Pluripotent Cell-derived Endoderm Differentiation Kit |
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| 関連記事 |
R&D Systems(R&Dシステムズ)社 ELISA用ペア抗体を使用したELISA 構築ガイド |
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Product Details
| Species Reactivity | Human |
|---|---|
| Label | Biotin |
| Immunogen | Chinese hamster ovary cell line CHO-derived recombinant human FOLR1Arg25-Met233Accession # P15328 |
| Source | Polyclonal Goat IgG |
| Purification | Antigen Affinity-purified |
| Specificity | Detects human FOLR1 in ELISAs and Western blots. In sandwich ELISAs, less than 0.2% cross-reactivity with recombinant human (rh) FOLR2, rhFOLR3, rhFOLR4 and recombinant mouse FOLR1 is observed. |
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Applications and Data
| Recommended Concentration | Sample | |
| Western Blot | 0.1 µg/mL | Recombinant Human FOLR1 (Catalog # 5646-FR) |
| Human FOLR1 Sandwich Immunoassay | Reagent | |
| ELISA Capture (Matched Antibody Pair) | 2-8 µg/mL | Human FOLR1 Antibody (Catalog #MAB5646 ) |
| ELISA Detection (Matched Antibody Pair) | 0.1-0.4 µg/mL | Human FOLR1 Biotinylated Antibody (Catalog #BAF5646 ) |
| ELISA Standard | Recombinant Human FOLR1 Protein, CF (Catalog #5646-FR ) | |
| Please Note: Optimal dilutions should be determined by each laboratory for each application.General Protocolsare available in the Technical Information section on our website. | Preparation and Storage | |
| Reconstitution | Reconstitute at 0.2 mg/mL in sterile PBS. | Reconstitution Buffer Available |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. | |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. | |
| 1 month, 2 to 8 °C under sterile conditions after reconstitution. | ||
| 6 months, -20 to -70 °C under sterile conditions after reconstitution. | ||
| Background: FOLR1 | Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37‑42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown (1, 2). Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage (3‑6). Human FOLR1 shares 83% amino acid sequence identity with mouse and rat FOLR1. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas (7, 8). It is critically required during early embryogenesis as shown in knockout mice which die in utero with gross morphological defects (9). FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface (6, 10). A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk (11). | |
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References
| Kelemen, L.E. (2006) Int. J. Cancer 119:243. | |
| Fowler, B. et al. (2001) Kidney Int. 59:S-221. | |
| Luhrs, C.A. et al. (1989) J. Biol. Chem. 264:21446. | |
| Lacey, S.W. et al. (1989) J. Clin. Invest. 84:715. | |
| Elwood, P.C. (1989) J. Biol. Chem. 264:14893. | |
| Rijnboutt, S. et al. (1996) J. Cell Biol. 132:35. | |
| Ross, J.F. et al. (1994) Cancer 73:2432. | |
| Parker, N. et al. (2005) Anal. Biochem. 338:284. | |
| Piedrahita, J.A. et al. (1999) Nat. Genet. 23:228. | |
| Paulos, C.M. et al. (2004) Mol. Pharmacol. 66:1406. | |
| Elwood, P.C. et al. (1991) J. Biol. Chem. 26:2346. | |
| Long Name: | Folate Receptor 1 |
| Entrez Gene IDs: | 2348 (Human); 14275 (Mouse); 171049 (Rat) |
| Alternate Names: | Adult folate-binding protein; FBP; folate binding protein; folate receptor 1 (adult); Folate receptor 1; folate receptor alpha; Folate receptor, adult; Folbp1; FOLR; FOLR1; FR-alpha; KB cells FBP; MOv18; Ovarian tumor-associated antigen MOv18 |
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Related Research Areas
| Cancer Biomarkers | ||
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Related Product & Information
| Background | FOLR1 |
|---|---|
| background_content | Background: FOLR1 Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37‑42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown (1, 2). Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage (3‑6). Human FOLR1 shares 83% amino acid sequence identity with mouse and rat FOLR1. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas (7, 8). It is critically required during early embryogenesis as shown in knockout mice which die in utero with gross morphological defects (9). FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface (6, 10). A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk (11). |
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Citations
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
- Targeting of folate receptor beta on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells.
Authors: Lynn R, Poussin M, Kalota A, Feng Y, Low P, Dimitrov D, Powell D
Blood, 2015;125(22):3466-76.
Species: Human
Sample Type: Whole Cells
Application: Neut - Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women.
Authors: Kelemen L, Brenton J, Parkinson C, C Whitaker H, Piskorz A, Csizmadi I, Robson P
PLoS ONE, 2014;9(5):e96542.
Species: Human
Sample Type: Serum
Application: ELISA detection - Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcvarepsilonRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity.
Authors: Rudman SM, Josephs DH, Cambrook H, Karagiannis P, Gilbert AE, Dodev T, Hunt J, Koers A, Montes A, Taams L, Canevari S, Figini M, Blower PJ, Beavil AJ, Nicodemus CF, Corrigan C, Kaye SB, Nestle FO, Gould HJ, Spicer JF, Karagiannis SN
Clin. Exp. Allergy, 2011;41(10):1400-1413.
Species: Human
Sample Type: Serum
Application: ELISA Development
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