抗CD21抗体(Anti-CD21, Mouse-Mono, APC antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information

価格

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Product Details

Species Reactivity	Human
Label	Allophycocyanin
Immunogen	Chinese hamster ovary cell line CHO-derived recombinant human CD21Ile21-Arg971Accession # P20023
Source	Monoclonal Mouse IgG1 Clone # 544408
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects human CD21 in direct ELISAs and Western blots.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry

Detection of CD21 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD19 APC‑conjugated Monoclonal Antibody (Catalog # FAB4867A) and either (A) Mouse Anti-Human CD21 PE‑conjugated Monoclonal Antibody (Catalog # FAB4909P) or (B) Mouse IgG1 Phycoerythrin Isotype Control (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.

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Related Product & Information

Entrez Gene IDs	1380 (Human); 12902 (Mouse); 289395 (Rat)
Background	CD21
background_content	Background: CD21 CD21, also known as EBV Receptor or CR2 is a 145 kDa member of the RCA (Receptors of Complement Activation) family of proteins. It is expressed on T cells, B cells, and follicular dendritic cells. On the B cell surface, it combines with the BCR and CD19 to form a B cell activating complex. Mature human CD21 is 1013 amino acids (aa) in length. It is a type I Transmembrane (TM) protein that contains a 951 aa Extracellular Domain (ECD) (aa 21-971) and a short 34 aa cytoplasmic tail. The ECD exhibits fifteen 60 aa SUSHI repeats. Soluble CD21 can be generated by cleavage near the TM domain. One potential splice variant shows a deletion of aa 847‑908, while another shows an insertion of 59 aa after Lys659. The ECD of human CD21 shares 71% aa identity with mouse CD21 ECD.

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