抗Mouse/Rat CCR2 Phycoerythrin抗体(Anti-Mouse/Rat CCR2 Phycoerythrin antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

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Product Details

Species Reactivity	Mouse
Label	Phycoerythrin
Immunogen	L1.2 mouse pro-B cell line transfected with mouse CCR2
Source	Monoclonal Rat IgG2B Clone # 475301
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects mouse CCR2 transfectants but not the parental cell line in flow cytometry. Does not detect HEK293 human embryonic kidney cell line transfected with mouse CCR5 in flow cytometry.

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Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry

Detection of CCR2 in Mouse Splenocytes byFlow Cytometry. Mouse splenocytes were stained with RatAnti-Mouse CCR2 PE‑conjugated Monoclonal Antibody (Catalog #FAB5538P) and Rat Anti-Mouse Gr‑1/Ly‑6GFluorescein‑conjugated Monoclonal Antibody (Catalog # FAB1037F).Quadrant marker was set based on isotype control antibody staining (Catalog # IC013P). View our protocol for StainingMembrane-associated Proteins.

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Related Product & Information

Entrez Gene IDs	729230 (Human); 12772 (Mouse); 60463 (Rat)
Background	CCR2
background_content	Background: CCR2 CCR2, also known as CD192, is a 38 kDa 7TM chemokine receptor that binds CCL2, CCL7, CCL8, CCL12 (in mouse only) and CCL13. CCR2 is expressed by multiple hematopoietic cells plus, endothelial cells, fibroblasts, and smooth muscle cells. It functions as an HIV fusion co-factor and facilitates T cell recruitment during inflammation. Mouse CCR2 shares 67% and 95% aa sequence identity with human and rat CCR2, respectively.

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Citations

1. Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1
   Authors: F Sasaki, T Koga, K Saeki, T Okuno, S Kazuno, T Fujimura, Y Ohkawa, T Yokomizo
   PLoS ONE, 2017;12(9):e0185133.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


2. Delayed decompression exacerbates ischemia-reperfusion injury in cervical compressive myelopathy
   Authors: PM Vidal, SK Karadimas, A Ulndreaj, AM Laliberte, L Tetreault, S Forner, J Wang, WD Foltz, MG Fehlings
   JCI Insight, 2017;2(11):.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


3. Recruitment of neutrophils mediated by V?2 ?? T cells deteriorate liver fibrosis induced by Schistosoma japonicum infection in C57BL/6 mice
   Authors: L Zheng, Y Hu, Y Wang, X Huang, Y Xu, Y Shen, J Cao
   Infect. Immun., 2017;0(0):.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


4. Distinct functions of CXCR4, CCR2, and CX3CR1 direct dendritic cell precursors from the bone marrow to the lung
   Authors: H Nakano, MR Lyons-Cohe, GS Whitehead, K Nakano, DN Cook
   J. Leukoc. Biol, 2017;0(0):.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


5. The Yin/Yan of CCL2: a minor role in neutrophil anti-tumor activity in vitro but a major role on the outgrowth of metastatic breast cancer lesions in the lung in vivo
   Authors: N Lavender, J Yang, SC Chen, J Sai, CA Johnson, P Owens, GD Ayers, A Richmond
   BMC Cancer, 2017;17(1):88.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


6. Mature dendritic cell derived from cryopreserved immature dendritic cell shows impaired homing ability and reduced anti-viral therapeutic effects
   Sci Rep, 2016;6(0):39071.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


7. AMPK-Activated Protein Kinase Suppresses Ccr2 Expression by Inhibiting the NF-kappaB Pathway in RAW264.7 Macrophages.
   Authors: Kumase F, Takeuchi K, Morizane Y, Suzuki J, Matsumoto H, Kataoka K, Al-Moujahed A, Maidana D, Miller J, Vavvas D
   PLoS ONE, 2016;11(1):e0147279.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


8. Alternatively activated macrophages determine repair of the infarcted adult murine heart
   J Clin Invest, 2016;0(0):.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


9. Tumor necrosis factor drives increased splenic monopoiesis in old mice
   Authors: D Loukov, A Naidoo, A Puchta, JL Marin, DM Bowdish
   J Leukoc Biol, 2016;0(0):.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


10. Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function
    Proc Natl Acad Sci USA, 2016;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Flow

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