抗Mouse/Rat CCR2 Fluorescein抗体(Anti-Mouse/Rat CCR2 Fluorescein antibody)

• 価格
• Product Details
• Applications and Data
• Related Product & Information
• Citations

価格

目次に戻る

Product Details

Species Reactivity	Mouse
Label	Fluorescein
Immunogen	L1.2 mouse pro-B cell line transfected with mouse CCR2
Source	Monoclonal Rat IgG2B Clone # 475301
Purification	Protein A or G purified from hybridoma culture supernatant
Specificity	Detects mouse CCR2 transfectants but not the parental cell line in flow cytometry. Does not detect HEK293 human embryonic kidney cell line transfected with mouse CCR5 in flow cytometry.

目次に戻る

Applications and Data

	Recommended Concentration	Sample
Flow Cytometry	10 µL/106 cells	See below

Flow Cytometry
	Detection of CCR2 in Mouse Splenocytes byFlow Cytometry. Mouse splenocytes were stained with RatAnti-Mouse CCR2 Fluorescein‑conjugated Monoclonal Antibody (Catalog# FAB5538F) and Rat Anti-Mouse Gr‑1/Ly‑6GPE‑conjugated Monoclonal Antibody (Catalog # FAB1037P).View our protocol for StainingMembrane-associated Proteins.

目次に戻る

Related Product & Information

Entrez Gene IDs	729230 (Human); 12772 (Mouse); 60463 (Rat)
Background	CCR2
background_content	Background: CCR2 CCR2, also known as CD192, is a 38 kDa 7TM chemokine receptor that preferentially binds CCL2, CCL7, and CCL13. CCR2 is expressed by multiple hematopoietic cells, endothelial cells, fibroblasts, neurons, and smooth muscle cells. It functions as an HIV fusion co-factor and facilitates T cell recruitment during inflammation. Two alternate splice forms (CCR2A and CCR2B) differ only by the addition of 14 amino acids to the intracellular carboxyl terminal. Mouse CCR2 shares 67% and 95% aa sequence identity with human and rat CCR2, respectively.

目次に戻る

Citations

1. Small molecule-based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes
   Authors: X Wu, KK Dayanand, RP Thylur, CC Norbury, DC Gowda
   J. Biol. Chem., 2017;0(0):.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


2. Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells
   J Immunol, 2016;0(0):.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


3. Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice
   Authors: S Wattananit, D Tornero, N Graubardt, T Memanishvi, E Monni, J Tatarishvi, G Miskinyte, R Ge, H Ahlenius, O Lindvall, M Schwartz, Z Kokaia
   J Neurosci, 2016;36(15):4182-95.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


4. Combined effect of insulin-like growth factor-1 and CC chemokine ligand 2 on angiogenic events in endothelial cells.
   Authors: Viana I, de Almeida M, Lins M, dos Santos Reis M, de Araujo Vieira L, Smaniotto S
   PLoS ONE, 2015;10(4):e0121249.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


5. Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis.
   Authors: Bonapace L, Coissieux M, Wyckoff J, Mertz K, Varga Z, Junt T, Bentires-Alj M
   Nature, 2015;515(7525):130-3.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


6. Differential TGF-beta Signaling in Glial Subsets Underlies IL-6-Mediated Epileptogenesis in Mice.
   Authors: Levy N, Milikovsky D, Baranauskas G, Vinogradov E, David Y, Ketzef M, Abutbul S, Weissberg I, Kamintsky L, Fleidervish I, Friedman A, Monsonego A
   J Immunol, 2015;195(4):1713-22.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


7. Myeloid-derived suppressor cells contribute to Staphylococcus aureus orthopedic biofilm infection.
   Authors: Heim, Cortney, Vidlak, Debbie, Scherr, Tyler D, Kozel, Jessica, Holzapfel, Melissa, Muirhead, David E, Kielian, Tammy
   J Immunol, 2014;192(8):3778-92.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow


8. Toxoplasma gondii profilin promotes recruitment of Ly6Chi CCR2+ inflammatory monocytes that can confer resistance to bacterial infection.
   Authors: Neal L, Knoll L
   PLoS Pathog, 2014;10(6):e1004203.
   Species: Mouse
   Sample Type: Whole Cells
   Application: Flow

目次に戻る