抗LAG3 [17B4]抗体 | Anti-LAG3 [17B4] antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

目次に戻る

価格

目次に戻る

製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	17B4
Isotype	IgG1
Application	WB, ICC/IF, IHC-Fr, IP, Functional Assay
Reactivity	Human

目次に戻る

APPLICATION

Application Note

Functional Assay: Inhibition, Immunohistochemistry frozen sections: 1:150, Immunoprecipitation: 10μg/ml, Western Blot: 5μg/ml

Calculated MW	57 kDa. ( Note )
Specificity/Sensitivity	Recognizes human LAG-3.

目次に戻る

PROPERTIES

Form	Liquid
Buffer	PBS containing 0.02% sodium azide.
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Synthetic peptide corresponding to 30 aa in the N-terminus of human LAG-3.
Purification	Protein A-affinity purified.
Purity	≧95% (SDS-PAGE)
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

目次に戻る

TARGET

Synonyms	Lymphocyte Activating 3 , Cd223 , Lag3
Background	Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Database	・ Gene ID: 3902 ・ UniProt: P18627

目次に戻る

REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Casati C et al. J Immunol 2008; 180 (6):687601 Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal for dendritic cell activation.
Triebel F et al. Cancer Lett 2006; 235 (1):147-53 A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors.
Di Carlo E et al. J Pathol 2005; 205 (1):82-91 Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway.
Macon-Lemaitre L et al. Immunology 2005; 115 (2):170-8 The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells.
Demeure CE et al. Eur J Cancer 2001; 37 (13):1709-18 T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts.

目次に戻る