抗HIF1 alpha [RM242]抗体 | Anti-HIF1 alpha [RM242] antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

	Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using Anti-HIF-1-alpha RM242at a 1:1000 dilution.
	Western Blot of Jurkat cell lysate, nontreated or treated with Cobalt(II) chloride (CoCl2), using Anti-HIF-1-alpha RM242 at a 1:1000 dilution, showed that HIF-1-alpha (~120 kDa) expressionwas induced by CoCl2 in Jurkat cells.

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製品情報

Host	Rabbit
Clonality	Monoclonal
Clone Name	RM242
Isotype	IgG
Application	WB, IHC-P, IHC
Reactivity	Human, Rat

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APPLICATION

Application Note

Immunohistochemistry (IHC): 1:500-1:1000 dilution, Western Blot (WB): 1:1000-1:2000 dilution.

Calculated MW	93 kDa. ( Note )
Specificity/Sensitivity	This antibody reacts to human HIF-1-alpha (Hypoxia-inducible factor 1-alpha).

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PROPERTIES

Form	Liquid
Buffer	50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Immunogen	A peptide corresponding to Hypoxia-inducible factor 1-alpha
Purification	Protein A affinity purified from an animal origin-free culture supernatant
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Hypoxia Inducible Factor 1 Subunit Alpha , Hif-1-Alpha , Hif-1A , Hif-1Alpha , Hif1 , Hif1-Alpha , Mop1 , Pasd8 , Bhlhe78 , Hif1A
Background	This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
Database	・ Gene ID: 3091 ・ UniProt: Q16665

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Gonzalez-Pacheco H et al. ScientificWorldJournal 2014; 2014 : 187071 Pre-conditioning with CDP-choline attenuates oxidative stress-induced cardiac myocyte death in a hypoxia/reperfusion model.	Application : WB Reactivity : Rat

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