抗E-Cadherin [RM244]抗体 | Anti-E-Cadherin [RM244] antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

	Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using Anti-E-cadherin RM244 at a 1:1000 dilution.
	Western Blot of MCF-7 cell lysates using Anti-E-cadherin RM244 at a 1:1000 dilution, showed a band of E-cadherin (~120 kDa) expressed in MCF-7 cells.

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製品情報

Host	Rabbit
Clonality	Monoclonal
Clone Name	RM244
Isotype	IgG
Application	WB, IHC-P
Reactivity	Human

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APPLICATION

Application Note

Immunohistochemistry (IHC): 1:500-1:1000 dilution, Western Blot (WB): 1:1000-1:2000 dilution.

Calculated MW	97 kDa. ( Note )
Specificity/Sensitivity	This antibody reacts to human E-cadherin (Cadherin-1).

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PROPERTIES

Form	Liquid
Buffer	50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Immunogen	A peptide corresponding to Cadherin-1
Purification	Protein A affinity purified from an animal origin-free culture supernatant
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Cadherin 1 , Arc-1 , Bcds1 , Cd324 , Cdhe , Ecad , Lcam , Uvo , Cdh1
Background	This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
Database	・ Gene ID: 999 ・ UniProt: P12830

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