抗Von Hippel Lindau抗体 | Anti-Von Hippel Lindau antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

	WB analysis of various sample lysates using GTX32968 Von Hippel Lindau antibody.Loading : 25ug per laneDilution : 1:1000
	IHC-P analysis of human tonsil tissue using GTX32968 Von Hippel Lindau antibody. Dilution : 1:200
	IHC-P analysis of mouse spleen tissue using GTX32968 Von Hippel Lindau antibody. Dilution : 1:200
	ICC/IF analysis of U-251MG cells using GTX32968 Von Hippel Lindau antibody.Blue : DAPIDilution : 1:100
	IHC-P analysis of rat ovary tissue using GTX32968 Von Hippel Lindau antibody. Dilution : 1:200

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, ICC/IF, IHC-P
Reactivity	Human, Mouse, Rat, Zebrafish

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	1:500-1:2000
ICC/IF	1:50-1:200
IHC-P	1:50-1:200

Not tested in other applications.

Calculated MW	24 kDa. ( Note )

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PROPERTIES

Form	Liquid
Buffer	PBS pH7.3, 0.02% sodium azide, 50% glycerol.
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human VHL (NP_937799.1).
Purification	Purified by affinity chromatography
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	von Hippel-Lindau tumor suppressor , HRCA1 , RCA1 , VHL1 , pVHL
Cellular Localization	Nucleus
Background	Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Database	・ Gene ID: 7428 VHL ・ UniProt: P40337 VHL

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