抗Beclin 1抗体 | Anti-Beclin 1 antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

	IHC-P analysis of mouse brain tissue using GTX31722 Beclin 1 antibody. Working concentration : 20 μg/ml
	IHC-P analysis of mouse brain tissue using GTX31722 Beclin 1 antibody. Working concentration : 2 μg/ml
	IHC-P analysis of human brain tissue using GTX31722 Beclin 1 antibody. Working concentration : 2.5 μg/ml
	IHC-P analysis of rat brain tissue using GTX31722 Beclin 1 antibody. Working concentration : 2 μg/ml
	IHC-P analysis of human brain tissue using GTX31722 Beclin 1 antibody. Working concentration : 20 μg/ml
	WB analysis of 293 cell lysate using GTX31722 Beclin 1 antibody. Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, ICC/IF, IHC-P, ELISA
Reactivity	Human, Mouse, Rat

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	0.5 - 2 μg/mL
ICC/IF	Assay dependent
IHC-P	2 μg/mL
ELISA	Assay dependent

Not tested in other applications.

Calculated MW	52 kDa. ( Note )
Positive Control	HEK293 Cell Lysate(GTX27902) , Mouse Brain Tissue Lysate(GTX27934)

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PROPERTIES

Form	Liquid
Buffer	PBS with 0.02% sodium azide.
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Beclin-1 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human Beclin-1.The immunogen is located within amino acids 40 - 90 of Beclin-1.
Purification	Purified by antigen-affinity chromatography
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	beclin 1 , ATG6 , VPS30 , beclin1
Cellular Localization	Cytoplasm,Endosome membrane,Endoplasmic reticulum membrane,Endosome,Nucleus
Background	Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010]
Database	・ Gene ID: 8678 BECN1 ・ UniProt: Q14457 BECN1

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Tang YJ et al. Drug Des Devel Ther 2019; 13 : 513-521 Bisperoxovanadium protects against spinal cord injury by regulating autophagy via activation of ERK1/2 signaling.
Smirnov AV et al. Bull Exp Biol Med 2018; 165 (1) : 105-109 Expression of Beclin-1 and LAMP-2 in Rat Hippocampus under Conditions of Simulated Gravity Overload in the Caudocranial Vector.	Application : IHC-P Reactivity : Rat
Lin S et al. Int J Biochem Cell Biol 2017; 87 : 54-68 endoplasmic reticulum-targeting photosensitizer hypericin confers chemo-sensitization towards * through inducing pro-death autophagy.	Application : WB Reactivity : Human

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