抗PD1 [NAT105]抗体 | Anti-PD1 [NAT105] antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

IHC-P analysis of human tonsil tissue using GTX20256 PD1 antibody [NAT105].

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	NAT105
Isotype	IgG1
Application	WB, ICC/IF, IHC-P, IHC-Fr, FACS, IP, IHC
Reactivity	Human, Mouse

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	Assay dependent
ICC/IF	Assay dependent
IHC-P	1:25-100
IHC-Fr	Assay dependent
FACS	Assay dependent
IP	Assay dependent
IHC	Assay dependent

Not tested in other applications.

Calculated MW	32 kDa. ( Note )

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PROPERTIES

Form	Liquid
Buffer	Tris Buffer pH 7.3-7.7, 1% BSA, 0.1% Sodium Azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Antigen Species	Human
Purification	Unpurified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	programmed cell death 1 , CD279 , PD-1 , PD1 , SLEB2 , hPD-1 , hPD-l , hSLE1
Cellular Localization	Membrane; Single-pass type I membrane protein
Background	This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
Database	・ Gene ID: 5133 PDCD1 ・ UniProt: Q15116 PDCD1

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Kammerer-Jacquet SF et al. Int J Cancer 2017; 140 (1):142-148 Independent association of PD-L1 expression with noninactivated VHL clear cell renal cell carcinoma-A finding with therapeutic potential.
Kaewkangsadan V et al. J Immunol Res 2016; 2016:4757405 Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer.	Application : IHC-P Reactivity : Human
Dronca RS et al. JCI Insight 2016; 1 (6) T cell Bim levels reflect responses to anti-PD-1 cancer therapy.	Application : IHC-P Reactivity : Human
Bastman JJ et al. J Clin Endocrinol Metab 2016; 101 (7):2863-73 Tumor-Infiltrating T Cells and the PD-1 Checkpoint Pathway in Advanced Differentiated and Anaplastic Thyroid Cancer.	Application : IHC Reactivity : Human
Li CW et al. Nat Commun 2016; 7:12632 Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.	Reactivity : Mouse

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