抗beta Catenin (phospho Ser33/Ser37) [BC-22]抗体 | Anti-beta Catenin (phospho Ser33/Ser37) [BC-22] antibody

• 2025/11/04

  試薬 特別価格

  [GNT]一次抗体製品25％OFFキャンペーン[～2026/02/27]

  期間：2025/11/04 ～2026/02/27

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  GeneTex International Corporation（GNT）

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	BC-22
Isotype	IgG2b
Application	WB, ELISA
Reactivity	Human, Mouse, Rat, Chicken

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	5-10 μg/ml
ELISA	Assay dependent

Not tested in other applications.

Calculated MW	85 kDa. ( Note )
Positive Control	HEK-293 cells treated with proteasome inhibitor MG132
Specificity/Sensitivity	The antibody is inhibited more efficiently by the pSer37 peptide than by the pSer33 peptide and is not inhibited by the nonphos­phorylated peptide. It does not detect the unphos­phorylated or the Ser33 phosphorylated protein and does not recognize phosphorylated plakoglobin.

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PROPERTIES

Form	Liquid
Buffer	0.01M PBS pH7.4, 15 mM sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	~2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	synthetic phosphopeptide corresponding to the region that contains serines 33 and 37 of human β-catenin.
Purification	Purified immunoglobulin
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	catenin beta 1 , CTNNB , EVR7 , MRD19 , armadillo
Cellular Localization	Cytoplasm,Nucleus,Cytoplasm, cytoskeleton,Cell junction,Cell membrane,Cell junction, synapse
Background	The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kD) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.
Database	・ Gene ID: 1499 CTNNB1 ・ UniProt: P35222 CTNNB1

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