抗VEGF Receptor 2 [260.4(KDR-2)] (Biotin)抗体 | Anti-VEGF Receptor 2 [260.4(KDR-2)] (Biotin) antibody

掲載日情報:2020/04/02 現在Webページ番号:188261

GeneTex社の抗VEGF Receptor 2 [260.4(KDR-2)] (Biotin)抗体 | Anti-VEGF Receptor 2 [260.4(KDR-2)] (Biotin) antibodyです。

本製品は研究用です。研究用以外には使用できません。

特長

  • 高品質の抗体です。
  • 幅広い研究分野に関連する抗体を取り揃えています。
  • 使用されたアプリケーションや動物種などの情報が充実しています。
  • 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

[在庫・価格 :2024年03月29日 20時15分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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納期 文献数
Anti-VEGF Receptor 2, Mouse-Mono(KDR-2 or 260.4), Biotin
2~3週間 ※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。 0
説明文
抗原:Extracellular fragment
別名:kinase insert domain receptor,CD309,FLK1,VEGFR,VEGFR2
クローン:260.4(KDR-2)
Genbank No: 3791
法規制等
保存条件 -20℃ 法規備考
抗原種 Human 免疫動物 Mouse クラス IgG 標識 Biotin
交差性 Human 適用 FCM,Western Blot
クロナリティ Monoclonal フォーマット 性状 Purified 吸収処理
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製品記事
関連記事 GeneTex社における抗体の品質管理

[在庫・価格 :2024年03月29日 20時15分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。

Anti-VEGF Receptor 2, Mouse-Mono(KDR-2 or 260.4), Biotin

文献数: 0

説明文 抗原:Extracellular fragment
別名:kinase insert domain receptor,CD309,FLK1,VEGFR,VEGFR2
クローン:260.4(KDR-2)
Genbank No: 3791
法規制等
保存条件 -20℃ 法規備考
抗原種 Human 免疫動物 Mouse
交差性 Human 適用 FCM,Western Blot
標識 Biotin 性状 Purified
吸収処理 クラス IgG
クロナリティ Monoclonal フォーマット
掲載カタログ

製品記事
関連記事 GeneTex社における抗体の品質管理



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製品情報

HostMouse
ClonalityMonoclonal
Clone Name260.4(KDR-2)
IsotypeIgG1
ApplicationWB, FACS
ReactivityHuman


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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:1,000
FACS Assay dependent
Not tested in other applications.

Calculated MW 152 kDa. ( Note )
Specificity/Sensitivity Reacts specifically with human VEGF receptor-2. This clone has also been termed 260.4. It does not recognize Flt1 (VEGFR-1), Flt4 (VEGFR-3), or platelet-derived growth factor receptor (PDGF-R).


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PROPERTIES

Form Liquid
Buffer PBS pH7.4, 1% bovine serum albumin, 15 mM sodium azide
Storage Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species Human
Immunogen purified recombinant human extracellular VEGF receptor-2 (KDR).
Purification Purified immunoglobulin
Conjugation Biotin
Note For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.


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TARGET

Synonyms kinase insert domain receptor , CD309 , FLK1 , VEGFR , VEGFR2
Cellular Localization Cell junction,Endoplasmic reticulum,Cytoplasm,Nucleus,Cytoplasmic vesicle
Background Vascular endothelial growth factor (VEGF), also called vasculotropin (VAS) and vascular permeability factor (VPF), is a member of a family of endothelial cell mitogens and angiogenic factors. VEGF is a homodimeric heparin-binding glycoprotein, which specifically stimulates the proliferation of endothelial cells isolated from both small and large vessels. These include endothelial cells from adrenal cortex, cerebral cortex, fetal and adult aorta and human umbilical vein. The mitogenic activity of VEGF appears to be stimulated by specific VEGF receptors (160-200 kDa) which can be found on the surface of various endothelial cells. VEGF binds to two structurally similar receptor tyrosine kinases; Flt17(fms-like tyrosine kinase 1, also known as VEGF Receptor 1), and KDR8 (kinase-insert domain containing receptor, also known as VEGF Receptor 2). The homologous gene for the human KDR gene is mouse Flk1 (fetal liver kinase 1) and rat TKrc Both receptors are members of a superfamily of receptor tyrosine kinases (RTKs) which include PDGF receptor, c-fms, M-CSF receptor and c-kit - the receptor for stem-cell factor. The KDR gene has been mapped to human chromosome 4q11-q12, which is the same locus of PDGF receptor and c-kit. The extracellular domains of KDR/Flk1 and Flt1 (approx. 90 kDa), have seven immunoglobulin-like domains and belong to the class III RTKs. This family includes also Flt4, which shares a high homology with the two VEGF receptors. Studies using KDR and Flt1 stably transfected endothelial cell lines have shown that these two receptors exhibit different affinities to VEGF and mediate different responses. KDR expressing cells show striking changes in cell morphology, actin reorganization and membrane ruffling, chemotaxis and mitogenicity in response to VEGF, while Flt1 expressing cells lack such responses. Both KDR and Flt1 are phosphorylated in response to VEGF, however KDR much more efficiently. KDR/Flk1 does not respond to placental growth factor (PlGF), a VEGF related growth factor, while Flt1 binds PlGF specifically. The expression pattern of the two receptors is somewhat different; Flt1 is predominately expressed in human placenta and human vascular endothelial cells, while KDR is more widely expressed in all vessel-derived endothelial cells but low in human and fetal bovine placenta. Both VEGF receptors (KDR and Flt1) are upregulated in human fetal and in adult kidney. It has been suggested that in human postnatal hematopoietic tissues, 0.1% to 0.5% of CD34+ cells express VEGF Receptor 2/KDR; pluripotent hematopoietic stem cells (HSCs) were found to be restricted to the CD34+KDR+ cell fraction, while lineage-committed hematopoietic progenitor cells (HPCs) were found in the CD34+KDR- subset. Antibodies that react specifically with VEGF receptors are useful for the study of the specific differential tissue expression and intracellular localization of the receptor in normal and neoplastic tissue.
Database ・ Gene ID: 3791 KDR
・ UniProt: P35968 KDR


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