抗VEGF Receptor 2抗体 | Anti-VEGF Receptor 2 antibody

掲載日情報:2020/04/02 現在Webページ番号:188259

GeneTex社の抗VEGF Receptor 2抗体 | Anti-VEGF Receptor 2 antibodyです。

本製品は研究用です。研究用以外には使用できません。

特長

  • 高品質の抗体です。
  • 幅広い研究分野に関連する抗体を取り揃えています。
  • 使用されたアプリケーションや動物種などの情報が充実しています。
  • 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

[在庫・価格 :2024年04月26日 11時55分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。
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  • 価格
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納期 文献数
Anti-VEGF Receptor 2, Goat-Poly
2~3週間 ※ 表示されている納期は弊社に在庫がなく、取り寄せた場合の目安納期となります。 1
説明文
別名:kinase insert domain protein receptor,6130401C07,Flk-1,Flk1,Krd-1,Ly73,VEGFR-2,VEGFR2,orv,sVEGFR-2
Genbank No: 16542
法規制等
保存条件 -20℃ 法規備考
抗原種 Mouse 免疫動物 Goat クラス IgG 標識 Unlabeled
交差性 Mouse 適用 FCM,IHC,Inhibition,Neutralising,Western Blot
クロナリティ Polyclonal フォーマット 性状 Purified 吸収処理
掲載カタログ

製品記事 使いっきり抗体
関連記事 GeneTex社における抗体の品質管理

[在庫・価格 :2024年04月26日 11時55分現在]

※ 表示されている納期は弊社に在庫が無く、取り寄せた場合の納期目安となります。

Anti-VEGF Receptor 2, Goat-Poly

文献数: 1

説明文 別名:kinase insert domain protein receptor,6130401C07,Flk-1,Flk1,Krd-1,Ly73,VEGFR-2,VEGFR2,orv,sVEGFR-2
Genbank No: 16542
法規制等
保存条件 -20℃ 法規備考
抗原種 Mouse 免疫動物 Goat
交差性 Mouse 適用 FCM,IHC,Inhibition,Neutralising,Western Blot
標識 Unlabeled 性状 Purified
吸収処理 クラス IgG
クロナリティ Polyclonal フォーマット
掲載カタログ

製品記事 使いっきり抗体
関連記事 GeneTex社における抗体の品質管理



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製品情報

HostGoat
ClonalityPolyclonal
IsotypeIgG
ApplicationWB, FACS, IHC, Neutralizing/Blocking
ReactivityMouse


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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.1-0.2 μg/ml
FACS 3-10 μg/ml
IHC 5-15 μg/ml
Neutralizing/Blocking 0.1-0.3 μg/ml

Note :

WB
using protease-digested sections of human and mouse skeletal muscle.

FACS
using protease-digested sections of mouse brown adipose tissue.

IHC
using mitochondrial extract of rat brown adipose tissue

Not tested in other applications.

Specificity/Sensitivity The antibody has the ability to neutralize the biological activity of recombinant mouse VEGF R2. It demonstates approximately 40% cross-reactivity with recombinant human VEGF R2, 2% cross-reactivty with recombinant mouse VEGF R1, and no cross-reactivity with recombinant human VEGF R1 and VEGF R3.


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PROPERTIES

Form Liquid
Buffer PBS containing carbohydrates
Storage Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species Mouse
Immunogen purified recombinant mouse VEGF R2 extracellular domain expressed in NSO cells.
Purification Purified by affinity chromatography
Conjugation Unconjugated
Note For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.


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TARGET

Synonyms kinase insert domain protein receptor , 6130401C07 , Flk-1 , Flk1 , Krd-1 , Ly73 , VEGFR-2 , VEGFR2 , orv , sVEGFR-2
Background Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate the proliferation of endothelial cells, induce angiogenesis, and increase vascular permeability in both large and small vessels. The mitogenic activity of VEGFs appears to be mediated by specific VEGF receptors. Vascular Endothelial Growth Factor Receptor 2 (VEGF Receptor 2, KDR, Flk1) is one of the five receptor tyrosine kinases (RTKs) (VEGF Receptor 1/Flt1, VEGF Receptor 2/KDR/Flk1, VEGF Receptor 3/Flt4, tie1 and tek/tie2) whose expression is almost exclusively restricted to endothelial cells. These RTKs play central roles in vasculogenesis and angiogenesis. Tie1 and tek/tie2 are a class of RTKs containing two immunoglobulin-like domains, three EGF homology domains and three fibronectin type III domains in their extracellular regions. VEGF Receptor 1/Flt1, VEGF Receptor 2/KDR/Flk1, and VEGF Receptor 3/Flt4 are members of the class III subfamily of RTKs containing seven immunoglobulin-like repeats in their extracellular domains. VEGF Receptor 1 and VEGF Receptor 2 are both expressed in an endothelial cell-specific manner. They are detectable in virtually all tissues in adults and embryos. Monocytes express VEGF Receptor 1 and VEGF Receptor 2. VEGF Receptor 2 is also expressed in pancreatic duct cells, hematopoietic stem cells, megakaryocytes, specific tumor cell types such as malignant melanoma cells, and retinal progenitor cells. In the retina, two functional VEGF Receptor 2 forms are expressed as a result of alternative splicing. VEGF Receptor 2 is a key marker for pluripotent hematopoietic stem cells. VEGF Receptor 1 and VEGF Receptor 2 are closely related in their putative roles in angiogenesis. VEGF Receptor 2 is involved in commitment of endothelial-cell lineages and to cell proliferation, while VEGF Receptor 1 seems to be responsible for guiding endothelial cells into the proper spatial organization of the lumen-containing vessels. VEGF Receptor 1 binds both PIGF and VEGF with high affinity, whereas VEGF Receptor 2 binds VEGF with high affinity but does not bind PIGF. Recombinant soluble VEGF Receptor 2/Fc chimera binds VEGF with high affinity and is a potent VEGF antagonist.
Database ・ Gene ID: 16542 Kdr


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REFERENCEE(抜粋)

Application ReferenceApplication/Reactivity
Than A et al. Nat Commun 2018; 9 (1) : 4433 Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery.Reactivity : Mouse


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お問い合わせ先

(テクニカルサポート 試薬担当)

reagent@funakoshi.co.jp

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