抗c-Myc [JAC6]抗体 | Anti-c-Myc [JAC6] antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Rat
Clonality	Monoclonal
Clone Name	JAC6
Isotype	IgG1
Application	WB, ICC/IF, IHC-Fr, IP
Reactivity	Human, Wheat

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	1/500-1/1,000
ICC/IF	Assay dependent
IHC-Fr	Assay dependent
IP	Assay dependent

Not tested in other applications.

Calculated MW	49 kDa. ( Note )
Specificity/Sensitivity	This antibody recognizes the sequence EQKLISEEDL.

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PROPERTIES

Form	Liquid
Buffer	PBS, 0.09% Sodium Azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1.0 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Amino acids 408-439 corresponding to the C-terminal region of human c-myc
Purification	Protein G purified From tissue culture supernatant
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Myc Proto-Oncogene, Bhlh Transcription Factor , Mrtl , Mycc , Bhlhe39 , C-Myc , Myc
Background	The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
Database	・ Gene ID: 4609 ・ UniProt: P01106

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Takenaka N et al. Int J Mol Sci 2019; 20 (21) A Crucial Role for the Small GTPase Rac1 Downstream of the Protein Kinase Akt2 in Insulin Signaling that Regulates Glucose Uptake in Mouse Adipocytes.
Hurni S et al. Plant J 2014; Powdery mildew resistance gene Pm8 derived from rye is suppressed by its wheat ortholog Pm3.	Application : WB Reactivity : Wheat
Yang L et al. J Biol Chem 2008; 283 (17) : 11823-31 The nucleolus exhibits an osmotically regulated gatekeeping activity that controls the spatial dynamics and functions of nucleolin.	Application : ICC/IF Reactivity : Human

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