抗IL12 Receptor beta1抗体 | Anti-IL12 Receptor beta1 antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Goat
Clonality	Polyclonal
Isotype	IgG
Application	WB, ELISA
Reactivity	Human

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	0.1-0.2 μg/ml
ELISA	0.5-1.0 μg/ml

Not tested in other applications.

Calculated MW	73 kDa. ( Note )
Positive Control	recombinant human IL-12 Rβ1
Specificity/Sensitivity	The antibody shows 5% cross-reactivity with recombinant mouse IL-12 Rβ1.

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PROPERTIES

Form	Liquid
Buffer	PBS
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	recombinant human IL-12 Rβ1 extracellular domain, expressed in NSO cells
Purification	Purified by affinity chromatography
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	interleukin 12 receptor subunit beta 1 , CD212 , IL-12R-BETA1 , IL12RB , IMD30
Cellular Localization	Membrane; Single-pass type I membrane protein
Background	Interleukin 12 (IL12) was identified as a factor secreted by human Epstein-Barr (EBV) transformed B cell lines. IL12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL12 is produced predominantly by monocytes and NK cells2 and induces T cells and NK cells to produce IFN gamma. Human IL12 is not active on mouse cells, but murine IL12 is active on both murine and human lymphocytes. IL12 signals through the IL12 receptor, which is composed of at least two subunits designated beta1 and beta2. Both IL12 receptor subunits are members of the hemapoietin receptor superfamily and have strong homology to the gp130 receptor. The beta1 receptor, although a low affinity binder of IL12, is not capable of transducing an IL12-mediated signal. A second subunit of the IL12 receptor was subsequently identified that when coexpressed with the beta1 subunit forms a high affinity receptor for IL12 and confers IL12 signaling.
Database	・ Gene ID: 3594 IL12RB1 ・ UniProt: P42701 IL12RB1

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