抗Rb2 / p130 [KAB40]抗体 | Anti-Rb2 / p130 [KAB40] antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	KAB40
Isotype	IgG1
Application	WB
Reactivity	Human, Mouse, Donkey

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APPLICATION

Application Note

WB: Use at a dilution of 1/1000. Detects a band of approximately 130 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW	128 kDa. ( Note )
Positive Control	CC3A whole cell lysate
Specificity/Sensitivity	Recognizes both phosphorylated and non-phosphorylated forms of Rb2 / p130 by immunoblotting.

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PROPERTIES

Form	Liquid
Buffer	Phosphate-buffered saline, pH 7.2, containing 0.08% Sodium Azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Recombinant fusion protein (Human).
Purification	Protein G purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Rb Transcriptional Corepressor Like 2 , P130 , Rb2 , Rbl2
Cellular Localization	Nuclear
Background	Two retinoblastoma related proteins, p107 and pRb2 / p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb / p105), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the ""pocket domain."" Like pRb, both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2 / p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer.
Database	・ Gene ID: 5934 ・ UniProt: Q08999

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