抗CD40L / CD154抗体 | Anti-CD40L / CD154 antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

目次に戻る

価格

目次に戻る

製品情報

Host	Goat
Clonality	Polyclonal
Isotype	IgG
Application	WB, FACS
Reactivity	Human

目次に戻る

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	1 μg/ml
FACS	Assay dependent

Not tested in other applications.

Calculated MW	29 kDa. ( Note )

目次に戻る

PROPERTIES

Form	Liquid
Buffer	PBS containing carbohydrates
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	purified recombinant human CD40 ligand C-terminal extracellular domain, expressed in E. coli.
Purification	Purified by affinity chromatography
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

目次に戻る

TARGET

Synonyms	CD40 ligand , CD154 , CD40L , HIGM1 , IGM , IMD3 , T-BAM , TNFSF5 , TRAP , gp39 , hCD40L
Cellular Localization	Cell membrane
Background	CD40 ligand (also known as CD154, TRAP, or gp39) is a 261 amino acid type II transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) superfamily. CD40L is expressed predominantly on activated CD4+ T lymphocytes. It is also found in other cell types (NK cells, mast cells, basophils, and eosinophils). Human and mouse CD40L share approximately 78% sequence identity. The receptor for CD40L is CD40. CD40, a type I transmembrane glycoprotein belonging to the TNF receptor family, is expressed on B lymphocytes, monocytes, dendritic cells, and thymic epithelium. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions central to the control of thymus-dependent humoral immunity and may be critical in the development of cell-mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. The interaction of CD40 and CD40L also plays important roles in monocyte activation and dendritic cell maturation. Activation of CD40 inhibits the growth of certain B cell lymphomas and induces the death of transformed cells of mesenchymal or epithelial origin.
Database	・ Gene ID: 959 CD40LG ・ UniProt: P29965 CD40LG

目次に戻る