抗MUC1 [M4H2]抗体 | Anti-MUC1 [M4H2] antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	M4H2
Isotype	IgG
Application	ICC/IF, IHC-P, IHC-Fr, ELISA, sELISA
Reactivity	Human

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
ICC/IF	Assay dependent
IHC-P	Assay dependent
IHC-Fr	Assay dependent
ELISA	Assay dependent
sELISA	Assay dependent
Note : ELISA This antibody can be used for detection of unglycosylated and glycosylated tumor-associated MUC1 mucins in human serum. sELISA Capture : GTX10120, Dection: GTX10120 (detection of unglycosylated MUC1) or Capture : GTX10120, Dection: GTX10118/GTX28323 (detection of glycosylated MUC1)

Not tested in other applications.

Calculated MW	25.41 kDa. ( Note )
Specificity/Sensitivity	Clone M4H2, M2F1, M2C5 bind with high efficiency with different epitopes within the VNTR tandem repeat peptide region of MUC1 molecule, which have different conformations and peptide-carbohydrate compositions. Clone M4H2 reacts with VNTR20 recombinant unglycosylated fragment of MUC1 protein, with monomeric VNTR MUC1 peptide, with deglycosylated and underglycosylated natural MUC1 protein.

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PROPERTIES

Form	Liquid
Buffer	PBS pH 7.4, 0.09 % sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4º C.
Concentration	Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Recombinant (E. coli) VNTR20 (tandem repeat in MUC1 core) polypeptide. This antibody binds with high efficiency with different epitopes within the VNTR tandem repeat peptide region of MUC1 molecule, which have different conformations and peptide-carbohydrate compositions.
Purification	Protein A purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Mucin 1, Cell Surface Associated , Admckd , Admckd1 , Ca 15-3 , Cd227 , Ema , H23Ag , Kl-6 , Mam6 , Mcd , Mckd , Mckd1 , Muc-1 , Muc-1/Sec , Muc-1/X , Muc1/Zd , Pem , Pemt , Pum , Muc1
Background	This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Database	・ Gene ID: 4582 ・ UniProt: A0A087X0L2

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