抗TOP2A, Mouse-Mono(UMAB146) UltraMAB抗体 | Anti-TOP2A, Mouse-Mono(UMAB146) UltraMAB Antibody

• 価格
• UltraMAB抗体について
• Product Data
• Reference Data
• Image

価格

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UltraMAB抗体について

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Product Data

Immunogen	Human recombinant protein fragment corresponding to amino acids 1100-1531 of human TOP2A(NP_001058) produced in E.coli.
Clone Name	Clone UMAB146	Isotype	IgG1
Species Reactivity	Human	Concentration	0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application	WB, IHC	Suggested Dilutions	WB 1:200, IHC 1:200,
Buffer	PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification	Purified from mouse ascites fluids by affinity chromatography

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Reference Data

Target Name	Homo sapiens topoisomerase (DNA) II alpha 170kDa (TOP2A)
Alternative Name	TOP2; TP2A
Database Link	NP_001058
Function	This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul
Related Pathway

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Image

WB Image	Western blot of cell lysates (35ug) from 9 different cell lines (1: HepG2, 2: HeLa, 3: SV-T2, 4: A549. 5: COS7, 6: Jurkat, 7: PC-12, 8: MDCK, 9: MCF7).
WB Image	Western blot analysis of  Jurkat cell lysate (35ug) by using anti-TOP2A monoclonal antibody.
IHC Image	Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-TOP2A mouse monoclonal antibody. (UM800043; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min)
IHC Image	Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TOP2A mouse monoclonal antibody. (UM800043; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min)
IHC Image	Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-TOP2A mouse monoclonal antibody. (UM800043; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min)
IHC Image	Immunohistochemical staining of paraffin-embedded Human tonsil using anti-TOP2A mouse monoclonal antibody. (UM800043; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min)

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