Luteolin (Alternative Name: 3',4',5,7-Tetrahydroxyflavone 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one) | 491-70-3

name

luteolin

chemical name

alternative name: 3',4',5,7-tetrahydroxyflavone 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4h-1-benzopyran-4-one

activity

anti-inflammatory, antioxidant and free radical scavenger. inhibits lps-induced tnf-α, il-6 and inducible nitric oxide production and blocks nf-κb and ap-1 activation. also inhibits tnf-α -induced cox-2 expression. antiproliferative and chemopreventative; inhibits proliferation of lewis lung carcinoma cells in vivo.

MW

286.24

Formula:

c15h10o6

Solubility:

soluble to 5 mm in 1eq. naoh and to 50 mm in dmso

Purity:

>98 %

Storage:

store at +4°c

CAS No:

491-70-3

Chen et al (2007) Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophage. Life Sci. 81 1602. PMID: 17977562.

Ju et al (2007) A critical role of luteolin-induced reactive oxygen species in blockage of tumour necrosis factor-activated nuclear factor-κB pathway and sensitization of apoptosis in lung cancer cells. Mol.Pharmacol. 71 1381. PMID: 17296806.

Kim et al (2007) Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma cells. Ann.N.Y.Acad.Sci. 1090 597.

Kim et al (2011) Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/ threonine kinase, inhibits tumor necrosis factor-α-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells. J.Pharm.Exp.Ther. 338 1013.