CGK 733 (α-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide) | 905973-89-9

name

cgk 733

chemical name

α-phenyl-n-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide

activity

originally defined as a selective inhibitor of atr and atm kinases. induces cell death in prematurely senescent breast cancer cells. decreases p21cip1 levels in premature senescent mcf-7 and hct-116 cells; also exhibits antiproliferative activity in a range of cancer cell lines. blocks camptothecin-induced p53 phosphorylation and protects cells from camptothecin-induced apoptosis.

MW

555.84

Formula:

c23h18cl3fn4o3s

Solubility:

soluble to 100 mm in dmso

Purity:

>98 %

Storage:

store at +4°c

CAS No:

905973-89-9

Crescenzi et al (2008) Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapy. Clin.Cancer Res. 14 1877. PMID: 18347191.

Cruet-Hennequart et al (2008) Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase η-deficient human cells treated with cisplatin and oxaliplatin. DNA Repair 7 582. PMID: 18289945.

Goldstein et al (2008) Apoptotic death induced by the cyclophosphamide analogue mafosfamide in human lymphoblastoid cells: Contribution of DNA replication, transcription inhibition and Chk/p53 signaling. Toxicol.Appl.Pharmacol. 229 20. PMID: 18289623.

Won et al (2008) Retraction: small molecule-based reversible reprogramming of cellular lifespan. Nat.Chem.Biol. 4 431. PMID: 18560433.

Alao and Sunnerhagen (2009) The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat.Oncol. 10 4. PMID: 19903334.

Bhattacharya et al (2009) Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells. Cell Signal. 21 509. PMID: 19136059.