8-Hydroxy-DPAT hydrobromide (Alternative Name: 8-OH-DPAT hydrobromide (±)-8-Hydroxy-2-dipropylaminotetralin hydrobromide) | 76135-31-4

name

8-hydroxy-dpat hydrobromide

chemical name

alternative name: 8-oh-dpat hydrobromide (±)-8-hydroxy-2-dipropylaminotetralin hydrobromide

activity

the standard selective 5-ht1a agonist. also has moderate affinity for 5-ht7 receptors (pki is 6.6 at the human 5-ht7 receptor expressed in hek 293 cells). reduces hippocampal 5-ht levels following systemic administration in rats in vivo. (r)-(+)-8-hydroxy-dpat hydrobromide (cat. no. 1080) and 7-hydroxy-dpat hydrobromide (cat. no. 0706) also available.

MW

328.29

Formula:

c16h25no.hbr

Solubility:

soluble to 20 mm in water with gentle warming

Purity:

>98 %

Storage:

desiccate at +4°c

CAS No:

76135-31-4

Middlemiss et al (1983) 8-OH-DPAT discriminates between subtypes of the 5HT₁ recognition site. Eur.J.Pharmacol. 90 151. PMID: 6223827.

Helton and Colbert (1994) Alteration of in-vitro 5-HT receptor pharmacology as a function of multiple treatment with 5-hydroxytryptamine of 8-hydroxy-2-(di-N-propylamino)tetralin in rat isolated aorta, uterus and fundus, and guinea pig isolated trachea. J.Pharm.Pharmacol. 46 902. PMID: 7897596.

Wood et al (2000) Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT₇ receptor. Eur.J.Pharmacol. 396 1. PMID: 10822046.

Yoshitake and Kehr (2004) Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 74 2865. PMID: 15050424.