Recombinant Human NT-3

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• 製品詳細
• 文献

価格

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製品詳細

name	Recombinant Human NT-3
Source	E.coli
Synonyms	Neurotrophin-3, Neurotrophic factor, Nerve growth factor-2, NGF-2, HGNF
AA Sequence (monomer)	MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml.
Description	NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4.  These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.  NT-3 is expressed by neurons of the central nervous systems, and can signal through the trk receptors.  NT-3 promotes the growth and survival of nerve and glial cells.  The amino acid sequences of human, murine and rat NT-3 are identical.  Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues).
Cross Reactivity	Chicken, Cow, Dog, Frog, Hamster, Human, Human + Virus, Monkey, Mouse, Pig, Rat

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文献

1. First Author:Liou, J C
   Title:Regulation of quantal secretion by neurotrophic factors at developing motoneurons in Xenopus cell cultures.
   Citation:The Journal of Physiology; 503(Pt 1):129-139.
   
2. First Author:Vicario-Abejon, C
   Title:Neurotrophins Induce Formation of Functional Excitatory and Inhibitory Synapses between Cultured Hippocampal Neurons.
   Citation:The Journal of Neuroscience; 18(18):7256-7271.
   
3. First Author:Pyle, A D
   Title:Neurotrophins mediate human embryonic stem cell survival.
   Citation:Nature Biotechnology; 24(3):344-50.
   
4. First Author:Soen, Y
   Title:Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments.
   Citation:Molecular Systems Biology; 2:37.
   
5. First Author:Li, W
   Title:Downstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons.
   Citation:BMC Biology; 8:86.
   
6. First Author:Iohara, K
   Title:Side population cells isolated from porcine dental pulp tissue with self-renewal and multipotency for dentinogenesis, chondrogenesis, adipogenesis, and neurogenesis.
   Citation:Stem Cells; 24(11):2493-503.
   
7. First Author:Cass, W A
   Title:Protection by GDNF and other trophic factors against the dopamine-depleting effects of neurotoxic doses of methamphetamine.
   Citation:Annals of the New York Academy of Sciences; 1074:272-81.
   
8. First Author:Qin, H
   Title:Regulation of Apoptosis and Differentiation by p53 in Human Embryonic Stem Cells.
   Citation:The Journal of Biological Chemistry; 282(8):5842-52.
   
9. First Author:Steiner, D
   Title:Derivation, propagation and controlled differentiation of human embryonic stem cells in suspension.
   Citation:Nature Biotechnology; 28(4):361-4
   
10. First Author:Jeanneteau, F
    Title:Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect.
    Citation:Proceedings of the National Academy of Sciences of the USA; 105(12):4862-7.
    

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