Recombinant Murine sCD40 Ligand

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• 製品詳細
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価格

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製品詳細

name	Recombinant Murine sCD40 Ligand
Source	E.coli
Synonyms	soluble CD40 Ligand, TNFSF5, TRAP, CD154, Gp39, T-BAM
AA Sequence	MQRGDEDPQI AAHVVSEANS NAASVLQWAK KGYYTMKSNL VMLENGKQLT VKREGLYYVY TQVTFCSNRE PSSQRPFIVG LWLKPSSGSE RILLKAANTH SSSQLCEQQS VHLGGVFELQ AGASVFVNVT EASQVIHRVG FSSFGLLKL
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	Determined by its ability to induce TNF-α and MIP-1α production by murine splenocytes. The expected ED50 for this effect is < 0.1 µg/ml.
Description	CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40 Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The soluble form of CD40L is an 18kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant Murine CD40L is a soluble 16.4 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.
Cross Reactivity	Human, Mouse, Rat

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文献

1. First Author:Suzuki, K
   Title:The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut.
   Citation:Immunity; 33(1):71-83
   
2. First Author:Yang, Y
   Title:IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation
   Citation:The Journal of Immunology; 174(5):2720-9
   
3. First Author:Chen, K
   Title:Induction of the Formyl Peptide Receptor 2 in Microglia by IFN-{gamma} and Synergy with CD40 Ligand.
   Citation:The Journal of Immunology; 178(3):1759-66
   
4. First Author:Ito, K
   Title:Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.
   Citation:The Journal of Immunology; 178(1):103-10.
   
5. First Author:Robles-Carrillo, L
   Title:Anti-CD40L immune complexes potently activate platelets in vitro and cause thrombosis in FCGR2A transgenic mice.
   Citation:The Journal of Immunology; 185(3):1577-83.
   
6. First Author:Tusche, M W
   Title:Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets.
   Citation:The Journal of Experimental Medicine; 206(12):2671-83.
   
7. First Author:Kim, T D
   Title:Organ-derived dendritic cells have differential effects on alloreactive T cells.
   Citation:Blood; 111(5):2929-40
   
8. First Author:Tsai, C M
   Title:Galectin-1 promotes immunoglobulin production during plasma cell differentiation.
   Citation:The Journal of Immunology; 181(7):4570-9.
   
9. First Author:Su, Y W
   Title:14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1.
   Citation:Proceedings of the National Academy of Sciences of the USA; 108(4):1555-60.
   
10. First Author:Franchi, L
    Title:Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation.
    Citation:The Journal of Immunology; 183(2):792-6.
    

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