Recombinant Murine TNF-α

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• 製品詳細
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価格

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製品詳細

name	Recombinant Murine TNF-α
Source	E.coli
Synonyms	Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin
AA Sequence	MLRSSSQNSS DKPVAHVVAN HQVEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLVY SQVLFKGQGC PDYVLLTHTV SRFAISYQEK VNLLSAVKSP CPKDTPEGAE LKPWYEPIYL GGVFQLEKGD QLSAEVNLPK YLDFAESGQV YFGVIAL
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	The ED50 as determined by the cytolysis of murine L929 cells in the presence of actinomycin D is ≤ 0.1 ng/ml, corresponding to a specific activity of  ≥ 1 x 107 units/mg.
Description	TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant Murine TNF-α is a soluble 156 amino acid protein (17.3 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
Cross Reactivity	Cow, Human, Human + Mouse, Monkey, Mouse, Mouse + Bacteria, Mouse + Chicken, Rat

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文献

1. First Author:Khaminets, A
   Title:Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.
   Citation:Cellular Microbiology; 12(7):939-61.
   
2. First Author:Kong, W
   Title:Docosahexaenoic acid prevents dendritic cell maturation and in vitro and in vivo expression of the IL-12 cytokine family.
   Citation:Lipids in Health and Disease; 9:12.
   
3. First Author:Ruth, J H
   Title:Interleukin 4 And 13 Participation In Mycobacterial (type-1) And Schistosomal (type 2) Antigen-Elicited Pulmonary Granuloma Formation: Multiparameter Analysis Of Cellular Recruitment, Chemokine Expression And Cytokine Networks.
   Citation:Cytokine; 12(5):432-44.
   
4. First Author:Marchiando, A M
   Title:Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo.
   Citation:The Journal of Cell Biology; 189(1):111-26.
   
5. First Author:Wang, C
   Title:Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine.
   Citation:The Journal of Immunology; 184(10):5519-26.
   
6. First Author:Sethu, S
   Title:Phospholipase D1 mediates TNFalpha-induced inflammation in a murine model of TNFalpha-induced peritonitis.
   Citation:PLoS ONE; 5(5):e10506.
   
7. First Author:Sander, L E
   Title:Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function.
   Citation:The Journal of Experimental Medicine; 207(7):1453-64.
   
8. First Author:Munder, M
   Title:Murine Macrophages Secrete Interferon y upon Combined Stimulation with Interleukin (IL)-12 and IL-18: A Novel Pathway of Autocrine Macrophage Activation
   Citation:The Journal of Experimental Medicine; 187(12):2103-2108.
   
9. First Author:König, K
   Title:Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration.
   Citation:The Journal of Immunology; 185(3):1466-75.
   
10. First Author:Cantelmo, A R
    Title:Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth.
    Citation:Oncogene; 29(38):5286-98.
    

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