Recombinant Human ENA-78 (CXCL5) (5-78 a.a.)

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• 製品詳細
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価格

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製品詳細

name	Recombinant Human ENA-78 (CXCL5) (5-78 a.a.)
Source	E.coli
Synonyms	Epithelial Neutrophil Activating Peptide-78, CXCL5
AA Sequence	AAVLRELRCV CLQTTQGVHP KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK KVIQKILDGG NKEN
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration of 5.0-10.0 ng/ml.
Description	ENA-78 is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78 is a chemoattractant for neutrophils. The three naturally occurring variants of human ENA-78; ENA 5-78, ENA 9-78 and ENA 10-78, contain 74, 70, and 69 amino acid residues, respectively, and possess the same biological activity. ENA-78 contains the four conserved cysteine residues present in CXC chemokines, and also contains the 'ELR' motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant Human ENA-78 is an 8.0 kDa protein consisting of 74 amino acid residues.
Cross Reactivity	Bacteria, Hamster, Human, Mouse

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文献

1. First Author:Nilsson, G
   Title:Mast Cell Migratory Response to Interleukin-8 Is Mediated Through Interaction With Chemokine Receptor CXCR2/Interleukin-8RB
   Citation:Blood; 93, Number 9. pp.2791-2797
   
2. First Author:Gerszten, R E
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3. First Author:Hirata, T
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   Citation:The Journal of Biological Chemistry; 279(50):51775-82.
   
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   Title:The role of HIV-related chemokine receptors and chemokines in human erythropoiesis in vitro
   Citation:Stem Cells; 2000;18(2):128-38
   
5. First Author:Luttichau, H R
   Title:The cytomegalovirus UL146 gene product vCXCL1 targets both CXCR1 and CXCR2 as an agonist.
   Citation:The Journal of Biological Chemistry; 285(12):9137-46.
   
6. First Author:Proost, P
   Title:Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation.
   Citation:The Journal of Experimental Medicine; 205(9):2085-97.
   
7. First Author:Egesten, A
   Title:SpeB of Streptococcus pyogenes differentially modulates antibacterial and receptor activating properties of human chemokines.
   Citation:PLoS ONE; 4(3):e4769.
   
8. First Author:Yung, S C
   Title:Host Chemokines Bind to Staphylococcus aureus and Stimulate Protein A Release.
   Citation:The Journal of Biological Chemistry; 286(7):5069-77.
   
9. First Author:Kechagia, J Z
   Title:Fibroblasts profiling in scarring trachoma identifies IL-6 as a functional component of a fibroblast-macrophage pro-fibrotic and pro-inflammatory feedback loop
   Citation:Scientific Reports; 6:28261
   
10. First Author:Singh, K
    Title:Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
    Citation:ACS Medicinal Chemistry Letters;
    

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