Recombinant Human PF-4 (CXCL4)

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• 製品詳細
• 文献

価格

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製品詳細

name	Recombinant Human PF-4 (CXCL4)
Source	E.coli
Synonyms	Platelet Factor-4, CXCL4, Oncostatin A, Ironplact
AA Sequence	EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	Determined by its ability to chemoattract human fibroblasts using a concentration range of 1.0-10.0 ng/ml.
Description	PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes, and has been shown to inhibit angiogenesis. Recombinant Human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.
Cross Reactivity	Bacteria, Human, Mouse, Trout

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文献

1. First Author:Schweickart, V L
   Title:CCR11 Is a Functional Receptor for the Monocyte Chemoattractant Protein Family of Chemokines.
   Citation:The Journal of Biological Chemistry; 275(13):9550-9556.
   
2. First Author:Gleissner, C A
   Title:CXC chemokine ligand 4 induces a unique transcriptome in monocyte-derived macrophages.
   Citation:The Journal of Immunology; 184(9):4810-8.
   
3. First Author:Feraud, O
   Title:Embryonic stem cell-derived embryoid bodies development in collagen gels recapitulates sprouting angiogenesis.
   Citation:Laboratory Investigation; 81(12):1669-81.
   
4. First Author:Hirata, T
   Title:Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus.
   Citation:The Journal of Biological Chemistry; 279(50):51775-82.
   
5. First Author:Schulze, H
   Title:Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions
   Citation:Blood; 104(13):3949-57
   
6. First Author:Oynebraten, I
   Title:Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase a and diacylglycerol
   Citation:The Journal of Immunology; 175(8):5358-69
   
7. First Author:Schiemann, F
   Title:Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G
   Citation:Blood; 107(6):2234-42
   
8. First Author:Bahar, M W
   Title:Structure and function of A41, a vaccinia virus chemokine binding protein.
   Citation:PLoS Pathogens; 4(1):e5.
   
9. First Author:Egesten, A
   Title:SpeB of Streptococcus pyogenes differentially modulates antibacterial and receptor activating properties of human chemokines.
   Citation:PLoS ONE; 4(3):e4769.
   
10. First Author:Kunert, S
    Title:The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation.
    Citation:Blood; 114(27):5532-40.
    

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