Recombinant Human MIP-1α (CCL3)

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価格

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製品詳細

name	Recombinant Human MIP-1α (CCL3)
Source	E.coli
Synonyms	Macrophage Inflammatory Protein-1α, CCL3, LD78α
AA Sequence	ASLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV IFLTKRSRQV CADPSEEWVQ KYVSDLELSA
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	Determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 ng/ml.
Description	Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1α and MIP-1β exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes, and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant Human MIP-1α is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Cross Reactivity	Bacteria, Cow, Frog, Hamster, Human, Human + Rat, Leech, Monkey, Mouse, Rat

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文献

1. First Author:Bryan, J D
   Title:Streptococcus agalactiae CspA is a serine protease that inactivates chemokines.
   Citation:Journal of Bacteriology; 191(6):1847-54.
   
2. First Author:Sabroe, I
   Title:Differential Regulation of Eosinophil Chemokine Signaling Via CCR3 and Non-CCR3 Pathways.
   Citation:The Journal of Immunology; 162(5):2946-55.
   
3. First Author:Oppermann, M
   Title:Differential Effects of CC Chemokine Receptor 5 (CCR5) Phosphorylation and Identification of Phosphorylation Sites on the CCR5 Carboxyl Terminus.
   Citation:The Journal of Biological Chemistry; 274(13):8875-8885.
   
4. First Author:Kitaura, M
   Title:Molecular Cloning of a Novel Human CC Chemokine (Eotaxin-3) That Is a Functional Ligand of CC Chemokine Receptor 3.
   Citation:The Journal of Biological Chemistry; 274(39):27975-27980.
   
5. First Author:Sabroe, I
   Title:A Small Molecule Antagonist of Chemokine Receptors CCR1 and CCR3.
   Citation:The Journal of Biological Chemistry; 275(34):25985-25992.
   
6. First Author:Aliberti, J
   Title:CCR5 provides a signal for microbial induced production of IL-12 by CD8a+ dendritic cells.
   Citation:Nature Immunology; 1(1):83-7.
   
7. First Author:Tiffany, H L
   Title:Amyloid-b Induces Chemotaxis and Oxidant Stress by Acting at Formylpeptide Receptor 2, a G Protein-coupled Receptor Expressed in Phagocytes and Brain.
   Citation:The Journal of Biological Chemistry; 276(26):23645-23652.
   
8. First Author:Tiffany, H L
   Title:Identification of CCR8: A Human Monocyte and Thymus Receptor for the CC Chemokine I-309
   Citation:The Journal of Experimental Medicine; 186(1):165-170.
   
9. First Author:Campbell, J J
   Title:Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions.
   Citation:Science; 279(5349):381.
   
10. First Author:Yoshida, T
    Title:Identification of Single C Motif-1/Lymphotactin Receptor XCR1
    Citation:The Journal of Biological Chemistry; 273(26): 16331-16334.
    

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