Recombinant Human IFN-γ

• 価格
• 製品詳細
• 画像
• 文献

価格

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製品詳細

name	Recombinant Human IFN-γ
Source	E.coli
Synonyms	Immune Interferon, type II interferon, T cell interferon, MAF
AA Sequence	MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	The ED50 determined by a cytotoxicity assay using HT-29 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
Description	IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells.  IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins.  This promotes the presentation of antigen to T-helper (CD4+) cells.  IFN-γ signaling in antigen-presenting cells, and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response.  Additionally, IFN-γ stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils.  Human IFN-γ is species-specific and is biologically active only in human and primate cells.  Recombinant Human IFN-γ is a 16.8 kDa protein containing 144 amino acid residues.
Cross Reactivity	Bacteria, Fish + Virus, Human, Human + Bacteria, Human + Mouse, Human + Virus, Leech, Mandarin Fish, Monkey, Mouse, N/A, Pig, Rabbit, Rat

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画像

Recombinant Human IFN-γ Biological Activity Graph

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文献

1. First Author:Wei, X
   Title:Inhibition of hepatitis C virus infection by interferon-gamma through downregulating claudin-1.
   Citation:Journal of Interferon & Cytokine Research; 29(3):171-8.
   
2. First Author:Gutwein, P
   Title:ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases.
   Citation:Journal of Biomedical Science; 17:3.
   
3. First Author:Azenshtein, E
   Title:The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity.
   Citation:Cancer Research; 62(4):1093-102.
   
4. First Author:Maertzdorf, J
   Title:IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts
   Citation:The Journal of Immunology; 169(10):5897-903.
   
5. First Author:Robson, N C
   Title:Processing and cross-presentation of individual HLA-A, -B, or -C epitopes from NY-ESO-1 or an HLA-A epitope for Melan-A differ according to the mode of antigen delivery.
   Citation:Blood; 116(2):218-25.
   
6. First Author:Vujanovic, L
   Title:Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15.
   Citation:Blood; 116(4):575-83
   
7. First Author:Kondo, A
   Title:Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.
   Citation:Blood; 116(7):1124-31
   
8. First Author:Fred, R G
   Title:High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression.
   Citation:PLoS ONE; 5(5):e10843.
   
9. First Author:Harui, A
   Title:Reconstitution of huPBL-NSG mice with donor-matched dendritic cells enables antigen-specific T-cell activation.
   Citation:Journal of Neuroimmune Pharmacology; 6(1):148-57.
   
10. First Author:De Almeida, D E
    Title:Immune dysregulation by the rheumatoid arthritis shared epitope.
    Citation:The Journal of Immunology; 185(3):1927-34.
    

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