Recombinant Murine IL-4

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• 製品詳細
• 文献

価格

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製品詳細

name	Recombinant Murine IL-4
Source	E.coli
Synonyms	BCGF, BCDF, B cell stimulating factor (BSF-1)
AA Sequence	MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	The ED50 was determined by the dose-dependent proliferation of murine HT-2 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Description	IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Murine IL-4 is a 13.5 kDa globular protein containing 121 amino acid residues.
Cross Reactivity	Bacteria, Human, Human + Mouse, Leech, Mouse, Mouse + Virus, N/A, Parasite, Pig Intestinal Worm, Rat, Trout

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文献

1. First Author:Zheng, X
   Title:RNAi-mediated CD40-CD154 interruption promotes tolerance in autoimmune arthritis.
   Citation:Arthritis Research & Therapy; 12(1):R13.
   
2. First Author:van Maldegem, F
   Title:Activation-induced cytidine deaminase splice variants are defective because of the lack of structural support for the catalytic site.
   Citation:The Journal of Immunology; 184(5):2487-91.
   
3. First Author:Sasaki, K
   Title:miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy.
   Citation:Journal of Translational Medicine; 8:17.
   
4. First Author:Ruth, J H
   Title:Interleukin 4 And 13 Participation In Mycobacterial (type-1) And Schistosomal (type 2) Antigen-Elicited Pulmonary Granuloma Formation: Multiparameter Analysis Of Cellular Recruitment, Chemokine Expression And Cytokine Networks.
   Citation:Cytokine; 12(5):432-44.
   
5. First Author:Macey, M R
   Title:IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis.
   Citation:The Journal of Immunology; 184(9):4688-95.
   
6. First Author:Denda-Nagai, K
   Title:Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells.
   Citation:The Journal of Biological Chemistry; 285(25):19193-204.
   
7. First Author:Coffey, F
   Title:Expression of cellular FLIP by B cells is required for their participation in an immune response.
   Citation:The Journal of Immunology; 184(9):4871-9.
   
8. First Author:Verginis, P
   Title:Delineation of five thyroglobulin T cell epitopes with pathogenic potential in experimental autoimmune thyroiditis
   Citation:The Journal of Immunology; 169(9):5332-7.
   
9. First Author:Zheng, X
   Title:Treatment of autoimmune arthritis using RNA interference-modulated dendritic cells.
   Citation:The Journal of Immunology; 184(11):6457-64.
   
10. First Author:Ma, F
    Title:The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice.
    Citation:Cellular and Molecular Immunology; 7(5):381-8.
    

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