Recombinant Murine IL-2

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• 製品詳細
• 画像
• 文献

価格

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製品詳細

name	Recombinant Murine IL-2
Source	E.coli
Synonyms	T-cell growth factor (TCGF), Aldesleukin
AA Sequence	PTSSSTSSST AEAQQQQQQQ QQQQQHLEQL LMDLQELLSR MENYRNLKLP RMLTFKFYLP KQATELKDLQ CLEDELGPLR HVLDLTQSKS FQLEDAENFI SNIRVTVVKL KGSDNTFECQ FDDESATVVD FLRRWIAFCQ SIISTSPQ
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	The ED50 as determined by the dose-dependent stimulation of murine CTLL-2 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
Description	IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation.  IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response.  IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.  Recombinant Murine IL-2 is a 17.2 kDa protein containing 148 amino acid residues.
Cross Reactivity	Human, Leech, Mouse, N/A

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画像

Recombinant Murine IL-2 Biological Activity Graph

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文献

1. First Author:Bersenev, A
   Title:Lnk constrains myeloproliferative diseases in mice.
   Citation:The Journal of Clinical Investigation; 120(6):2058-69
   
2. First Author:Mace, E M
   Title:Elucidation of the integrin LFA-1-mediated signaling pathway of actin polarization in natural killer cells.
   Citation:Blood; 116(8):1272-9.
   
3. First Author:Suto, A
   Title:Murine Plasmacytoid Dendritic Cells Produce IFN-{gamma} upon IL-4 Stimulation
   Citation:The Journal of Immunology; 175(9):5681-9
   
4. First Author:Park, H
   Title:Interaction of fas ligand and fas expressed on osteoclast precursors increases osteoclastogenesis
   Citation:The Journal of Immunology; 175(11):7193-201
   
5. First Author:Coloff, J L
   Title:Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.
   Citation:The Journal of Biological Chemistry; 286(7):5921-33.
   
6. First Author:Woolf, E
   Title:Runx3 regulates dendritic epidermal T cell development.
   Citation:Developmental Biology; 303(2):703-14.
   
7. First Author:Gu, F
   Title:Sustained release of bioactive therapeutic proteins from a biodegradable elastomeric device.
   Citation:Journal of Controlled Release; 117(1):80-9.
   
8. First Author:Kreymborg, K
   Title:IL-22 Is Expressed by Th17 Cells in an IL-23-Dependent Fashion, but Not Required for the Development of Autoimmune Encephalomyelitis.
   Citation:The Journal of Immunology; 179(12):8098-104.
   
9. First Author:Shimaoka, T
   Title:Critical Role for CXC Chemokine Ligand 16 (SR-PSOX) in Th1 Response Mediated by NKT Cells.
   Citation:The Journal of Immunology; 179(12):8172-9.
   
10. First Author:Hara, H
    Title:Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9.
    Citation:The Journal of Immunology; 181(2):918-30.
    

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