Recombinant Murine IL-13

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• 製品詳細
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価格

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製品詳細

name	Recombinant Murine IL-13
Source	E.coli
Synonyms	NC300 (Human), P600 (Murine)
AA Sequence	MPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 4.0 ng/ml, corresponding to a specific activity of ≥ 2.5 x 105 units/mg.
Description	IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells.  Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites.  IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8.  IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE.  Blocking of IL-13 activity inhibits the pathophysiology of asthma.  Human and murine IL-13 are cross-species reactive.  Recombinant Murine IL-13 is a 12.3 kDa protein consisting of 111 amino acid residues.
Cross Reactivity	Human, Mouse

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文献

1. First Author:Ge, Q
   Title:Homeostatic T cell proliferation in a T cell-dendritic cell coculture system.
   Citation:Proceedings of the National Academy of Sciences of the USA; 99(5):2983-2988.
   
2. First Author:Nagarkar, D R
   Title:Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages.
   Citation:The Journal of Immunology; 185(4):2525-35.
   
3. First Author:Suto, A
   Title:Murine Plasmacytoid Dendritic Cells Produce IFN-{gamma} upon IL-4 Stimulation
   Citation:The Journal of Immunology; 175(9):5681-9
   
4. First Author:Milner, J D
   Title:Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation.
   Citation:Blood; 116(14):2476-83
   
5. First Author:Mackinnon, A C
   Title:Regulation of Alternative Macrophage Activation by Galectin-3.
   Citation:The Journal of Immunology; 180(4):2650-2658.
   
6. First Author:Nemeth, K
   Title:Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma.
   Citation:Proceedings of the National Academy of Sciences of the USA; 107(12):5652-7.
   
7. First Author:Medoff, B D
   Title:CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation.
   Citation:The Journal of Immunology; 182(1):623-35.
   
8. First Author:Lim, R H
   Title:Transplacental passage of interleukins 4 and 13?
   Citation:PLoS ONE; 4(3):e4660.
   
9. First Author:Marathe, C
   Title:Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow
   Citation:Journal of Lipid Research; 50(2):214-24
   
10. First Author:Goswami, S
    Title:Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma.
    Citation:Nature Immunology; 10(5):496-503.
    

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