Recombinant Human IL-21

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• 製品詳細
• 画像
• 文献

価格

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製品詳細

name	Recombinant Human IL-21
Source	E.coli
Synonyms	Interleukin-21, Za11
AA Sequence	MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	Determined by its ability to stimulate the proliferation of human ANBL-6 cells. The expected ED50 is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x106 units/mg.
Description	IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include: inducing the differentiation of T-cell-stimulated B-cells into plasma cells and memory B-cells; the stimulation of IgG production in conjunction with IL-4; and the induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Human IL-21 is a 15.4 kDa protein consisting of 132 amino acid residues.
Cross Reactivity	Human, Mouse

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画像

Recombinant Human IL-21 Biological Activity Graph

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文献

1. First Author:Good, K L
   Title:Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21.
   Citation:The Journal of Immunology; 177(8):5236-47.
   
2. First Author:Lee, S H
   Title:Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.
   Citation:The Journal of Immunology; 185(2):917-28.
   
3. First Author:Lindemann, M J
   Title:Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway.
   Citation:The Journal of Biological Chemistry; 283(20):14100-8.
   
4. First Author:Tran, E
   Title:Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines.
   Citation:PLoS ONE; 5(12):e15625.
   
5. First Author:Pal, R
   Title:C/EBPbeta regulates transcription factors critical for proliferation and survival of multiple myeloma cells.
   Citation:Blood; 114(18):3890-8
   
6. First Author:Ma, C S
   Title:Early commitment of naive human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.
   Citation:Immunology and Cell Biology; 87(8):590-600.
   
7. First Author:Suryani, S
   Title:Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells.
   Citation:Blood; 115(3):519-29.
   
8. First Author:Avery, D T
   Title:B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans.
   Citation:The Journal of Experimental Medicine; 207(1):155-71, S1-5.
   
9. First Author:Kis, L L
   Title:IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter.
   Citation:Proceedings of the National Academy of Sciences of the USA; 107(2):872-7.
   
10. First Author:Kis, L L
    Title:STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.
    Citation:Blood; 117(1):165-74.
    

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