Recombinant Human IL-1β

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• 製品詳細
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価格

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製品詳細

name	Recombinant Human IL-1β
Source	E.coli
Synonyms	Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
AA Sequence	APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	The ED50 as determined by the dose-dependent stimulation of thymidine uptake by murine D10S cells is ≤ 1.0 pg/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg.
Description	IL-1β is a proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells.  Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties.  These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells.  However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine.  Recombinant Human IL-1β is a 17.3 kDa protein containing 153 amino acid residues.
Cross Reactivity	Bacteria, Cow, Frog, Human, Human + Mouse, Human + Rat, Monkey, Mouse, Mouse + Chicken, Pig, Rabbit, Rat, Sheep

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文献

1. First Author:Ali, S
   Title:Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes.
   Citation:International Journal of Biochemistry & Cell Biology; 42(1):113-9.
   
2. First Author:Hill, A L
   Title:Regulation of pentraxin-3 by antioxidants.
   Citation:British Journal of Anaesthesia; 103(6):833-9.
   
3. First Author:Thoh, M
   Title:Azadirachtin interacts with the tumor necrosis factor (TNF) binding domain of its receptors and inhibits TNF-induced biological responses.
   Citation:The Journal of Biological Chemistry; 285(8):5888-95.
   
4. First Author:Maertzdorf, J
   Title:IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts
   Citation:The Journal of Immunology; 169(10):5897-903.
   
5. First Author:Burgler, S
   Title:RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter.
   Citation:The Journal of Immunology; 184(11):6161-9.
   
6. First Author:Blanchet, F P
   Title:Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses.
   Citation:Immunity; 32(5):654-69
   
7. First Author:Kondo, A
   Title:Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.
   Citation:Blood; 116(7):1124-31
   
8. First Author:Fred, R G
   Title:High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression.
   Citation:PLoS ONE; 5(5):e10843.
   
9. First Author:Vigetti, D
   Title:Proinflammatory cytokines induce hyaluronan synthesis and monocyte adhesion in human endothelial cells through hyaluronan synthase 2 (HAS2) and the nuclear factor-kappaB (NF-kappaB) pathway.
   Citation:The Journal of Biological Chemistry; 285(32):24639-45.
   
10. First Author:Cella, M
    Title:Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity.
    Citation:Proceedings of the National Academy of Sciences of the USA; 107(24):10961-6.
    

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