Recombinant Human TGF-β3

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• 製品詳細
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• 文献

価格

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製品詳細

name	Recombinant Human TGF-β3
Source	E.coli
Synonyms	Transforming Growth Factor-β3
AA Sequence (monomer)	ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS
Purity	≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity	The ED50 was determined by TGF-β3’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
Description	The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown, but its expression pattern suggests a role in the regulation of certain development processes. Recombinant Human TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
Cross Reactivity	Cow, Dog, Human, Human + Virus, Mouse, Pig, Rat

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画像

Recombinant Human TGF-β3 Biological Activity Graph

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文献

1. First Author:Hoben, G M
   Title:Fibrochondrogenesis of hESCs: Growth factor combinations and co-cultures
   Citation:Stem Cells and Development;
   
2. First Author:Vogel, T
   Title:Transforming growth factor beta promotes neuronal cell fate of mouse cortical and hippocampal progenitors in vitro and in vivo: identification of Nedd9 as an essential signaling component.
   Citation:Cerebral Cortex; 20(3):661-71.
   
3. First Author:Mendez-Ferrer, S
   Title:Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.
   Citation:Nature; 466(7308):829-34.
   
4. First Author:Tran, D Q
   Title:GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.
   Citation:Proceedings of the National Academy of Sciences of the USA; 106(32):13445-50.
   
5. First Author:Qin, J
   Title:A stem cell-based tool for small molecule screening in adipogenesis.
   Citation:PLoS ONE; 5(9):e13014.
   
6. First Author:Fan, G
   Title:Isolation of mouse mesenchymal stem cells with normal ploidy from bone marrows by reducing oxidative stress in combination with extracellular matrix.
   Citation:BMC Cell Biology; 12:30.
   
7. First Author:Devine, M J
   Title:Parkinson's disease induced pluripotent stem cells with triplication of the a-synuclein locus.
   Citation:Nature Communications; 2:440
   
8. First Author:Lee, D S
   Title:Crosstalk between nuclear factor I-C and transforming growth factor-beta1 signaling regulates odontoblast differentiation and homeostasis.
   Citation:PLoS ONE; 6(12):e29160
   
9. First Author:Yoshida, M
   Title:TGF-β-operated growth inhibition and translineage commitment into smooth muscle cells of periodontal ligament-derived endothelial progenitor cells through Smad- and p38 MAPK-dependent signals.
   Citation:International Journal of Biological Sciences; 8(7):1062-74
   
10. First Author:Krawetz, R J
    Title:Synovial fluid progenitors expressing CD90+ from normal but not osteoarthritic joints undergo chondrogenic differentiation without micro-mass culture.
    Citation:PLoS ONE; 7(8):e43616
    

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