抗Sialosyl-Tn antigen [STn 219]抗体 | Anti-Sialosyl-Tn antigen [STn 219] antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	STn 219
Isotype	IgG1
Application	ICC/IF, IHC
Reactivity	Human

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APPLICATION

Application Note

IHC, ICC (frozen or formalin–fixed paraffin-embedded (FFPE) tissue sections, cell smears. For IHC dilute conc. antibodies 1:50-1:100, use streptavidin~biotin system or polymer system, incubate 30 minutes at room temperature.

Positive Control	Human gastrointestinal tumor, prostate, ovary ca.

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PROPERTIES

Form	Liquid
Buffer	PBS, pH7.2 containing 1% BSA and 0.05% sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration	0.20 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Ovine submaxillary mucin (OSM)
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	CD175s antibody , Sialosyl Tn antibodys , Tn antibody
Cellular Localization	Cytoplasmic, apical membrane, luminal
Background	Sialyl-Tn is a carbohydrate antigen overexpressed in several epithelial cancers including breast cancer, and usually associated with poor prognosis. Sialyl-Tn is synthesized by a CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase: ST6GalNAc I, which catalyzes the transfer of a sialic acid residue in alpha2,6-linkage to the GalNAcalpha1-O-Ser/Thr structure. The resulting disaccharide (Neu5Acalpha2-6GalNAcalpha1-O-Ser/Thr) cannot be further elongated and sialyl-Tn expression results therefore in a shortening of the O-glycan chains

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