抗CD3 epsilon [APA1/1] (PE)抗体 | Anti-CD3 epsilon [APA1/1] (PE) antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

FACS analysis of Jurkat cells using GTX80237 CD3 (activation epitope) antibody [APA1/1] (PE)

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	APA1/1
Isotype	IgG1
Application	FACS
Reactivity	Human, Mouse

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
FACS	Assay dependent

Not tested in other applications.

Calculated MW	23 kDa. ( Note )
Specificity/Sensitivity	This antibody recognizes an activation-dependent intracellular epitope of CD3 epsilon. Exposure of the epitope precedes CD3 phosphorylation and recruitment and activation of ZAP70, which initiates the signaling cascade produced by T-cell activation. APA1/1 provides the earliest known marker for TCR-mediated T cell activation.

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PROPERTIES

Form	Liquid
Buffer	PBS, 15mM sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
Concentration	0.1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Purified human CD3 proteins isolated from thymus
Purification	Purified by size-exclusion chromatography
Conjugation	Phycoerythrin (PE)
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	CD3E,CD3e molecule,IMD18,T3E,TCRE,CD3 epsilon
Cellular Localization	Membrane
Background	The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
Database	・ Gene ID: 916 CD3E ・ UniProt: P07766 CD3E

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