抗Fas [LT95] (PE)抗体 | Anti-Fas [LT95] (PE) antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

FACS analysis of human peripheral blood using GTX80054 Fas antibody [LT95] (PE).

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	LT95
Isotype	IgG1
Application	FACS
Reactivity	Human

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
FACS	20 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension

Not tested in other applications.

Calculated MW	38 kDa. ( Note )
Specificity/Sensitivity	This antibody recognizes a functional epitope of Fas molecule.

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PROPERTIES

Form	Liquid
Buffer	PBS, 15mM sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
Concentration	Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	HUT-78 human T cell lymphoma cell line
Purification	Purified by size-exclusion chromatography
Conjugation	Phycoerythrin (PE)
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	ALPS1A,APO1,APT1,CD95,FAS,FAS1,FASTM,Fas cell surface death receptor,TNFRSF6,Fas
Cellular Localization	Cell membrane,Secreted
Background	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
Database	・ Gene ID: 355 FAS ・ UniProt: P25445 FAS ・ UniProt: Q5T9P3

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