抗TCR Beta F1 [8A3]抗体 | Anti-TCR Beta F1 [8A3] antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

目次に戻る

価格

目次に戻る

DATA IMAGES

FACS analysis of Jurkat cells using GTX79388 TCR Beta F1 antibody [8A3] compared to an isotype control (blue).Dilution : 2 ug/test for 60 min at room temperatureFixation : 2% paraformaldehyde

目次に戻る

製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	8A3
Isotype	IgG1
Application	WB, ICC/IF, IHC-P, FACS, IP, ELISA, IHC
Reactivity	Human, Mouse, Yeast, Primate

目次に戻る

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	Assay dependent
ICC/IF	Assay dependent
IHC-P	Assay dependent
FACS	2 μg/test
IP	Assay dependent
ELISA	Assay dependent
IHC	Assay dependent

Not tested in other applications.

目次に戻る

PROPERTIES

Form	Liquid
Buffer	PBS, 0.5% BSA, 0.1% sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	0.15 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Human TCR β chain constant region
Purification	Protein G purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

目次に戻る

TARGET

Synonyms	T cell receptor beta locus , TCRB , TRB@
Background	T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq, Jul 2008]
Database	・ Gene ID: 6957 TRB

目次に戻る

REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Zhu D et al. Environ Microbiol 2019; 21 (8) : 3076-3090 Cwp22, a novel peptidoglycan cross-linking enzyme, plays pleiotropic roles in Clostridioides difficile.	Application : ELISA
Yoshioka Y et al. J Clin Exp Hematop 2015; 55 (1) : 17-21 T-Cell Prolymphocytic Leukemia, Small Cell Variant, Possibly at the Stage of Intracytoplasmic Expression of CD3 in T-Cell Ontogenesis.	Reactivity : Human

目次に戻る