抗Macrophage + Monocytes [MAC387]抗体 | Anti-Macrophage + Monocytes [MAC387] antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	MAC387
Isotype	IgG1
Application	IHC-P, IHC-Fr, FACS
Reactivity	Human, Mouse, Rat, Rabbit, Goat, Bovine, Cat, Dog, Guinea pig, Baboon, Cynomolgus monkey, Fallow deer, Horse, MarmosetPig, Mink, Pygmy hippopotamus, Rhesus Monkey

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
IHC-P	1/100-1/200
IHC-Fr	1/100-1/200
FACS	1/50-1/100
Note : IHC-P This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase. FACS Membrane permeabilisation is required for this application. Use 10μl of the suggested working dilution to label 106 cells in 100μl.

Not tested in other applications.

Specificity/Sensitivity	The antigen recognized by clone MCA387 is expressed by granulocytes, monocytes and by tissue macrophages. Variable results have been reported for staining brain macrophages and microglia.

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PROPERTIES

Form	Liquid
Buffer	PBS, 0.09% Sodium Azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1.0 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Human monocytes.
Purification	Protein G purified From tissue culture supernatant
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Background

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. [provided by RefSeq, Jul 2008]

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Passmore MR et al. Respir Res 2018; 19 (1) : 231 Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock.	Application : IHC-P Reactivity : Human
Lagumersindez-Denis N et al. Acta Neuropathol 2017; (Epub) Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis.	Application : IHC-P Reactivity : Mouse
Passmore M et al. Am J Physiol Lung Cell Mol Physiol 2016; : ajplung.00296.2016 Inflammation and Lung Injury in an Ovine Model of Extracorporeal Membrane Oxygenation Support.	Application : IHC-P
Feng PH et al. Am J Respir Crit Care Med 2012; 186 (10) : 1025-36 CD14(+)S100A9(+) monocytic myeloid-derived suppressor cells and their clinical relevance in non-small cell lung cancer.

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