抗Caspase 3抗体 | Anti-Caspase 3 antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P, IP, IHC
Reactivity	Human, Mouse, Rat, Rabbit

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APPLICATION

Application Note

For IHC-P: Use at a dilution of 1:1,000. For IP: Use at a dilution of 1:2,000. For WB: Use at a dilution of 1:500. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW	32 kDa. ( Note )
Positive Control	Jurkat Cells, Tonsil

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PROPERTIES

Form	Liquid
Buffer	10mM Phosphate-buffered saline containing 0.2% BSA and 0.1% sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Recombinant full length human caspase 3 protein.
Purification	Protein A affinity purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Caspase 3 , Cpp32 , Cpp32B , Sca-1 , Casp3
Cellular Localization	Cytoplasmic
Background	Caspase 3 is ubiquitously expressed and like other caspases is synthesized as an inactive (32 kD) proenzyme. Recent studies have implicated that Caspase 3 is associated with the induction of apoptosis. Activation of Caspase 3 occurs in response to variety of apoptotic inducers including Fas mediated apoptosis. Upon activation, Caspase 3 is cleaved at Asp28-Ser29 and Asp175-Ser176, thereby generating two subunits of 17 kD and 12 kD, respectively.
Database	・ Gene ID: 836 ・ UniProt: P42574

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
MALEK AZIZ et al. Canadian Journal of Physiology and Pharmacology 2019; (Epub) Protective Effects of Olmesartan and L-carnitine on Doxorubicin-Induced Cardiotoxicity in Rats.
Saat N et al. Biotech Histochem 2019; : 1-7 Effect of melatonin on torsion and reperfusion induced pathogenesis of rat uterus.	Application : IHC-P Reactivity : Rat
Wu KJ et al. Evid Based Complement Alternat Med 2012; 2012 : 656150 Guizhi-Fuling-Wan, a Traditional Chinese Herbal Medicine, Ameliorates Memory Deficits and Neuronal Apoptosis in the Streptozotocin-Induced Hyperglycemic Rodents via the Decrease of Bax/Bcl2 Ratio and Caspase-3 Expression.	Application : IHC Reactivity : Mouse
F?rat U et al. Exp Diabetes Res 2012; 2012 : 316384 Increased caspase-3 immunoreactivity of erythrocytes in STZ diabetic rats.	Application : IHC Reactivity : Rat

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