抗HAS2 [4E7]抗体 | Anti-HAS2 [4E7] antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

	IHC-P analysis of ovarian cancer tissue using GTX60647 HAS2 antibody [4E7].
	WB analysis of NTERA-2 (1), HEK293 (2) cell lysate using GTX60647 HAS2 antibody [4E7].
	ELISA analysis of antigen using GTX60647 HAS2 antibody [4E7]. Black : Control antigen 100ng Purple : Antigen 10ng Blue : Antigen 50ng Red : Antigen 100ng
	ICC/IF analysis of HeLa cells using GTX60647 HAS2 antibody [4E7].Green : HAS2 Blue: DRAQ5 fluorescent DNA dye Red: Actin filaments

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	4E7
Isotype	IgG1
Application	WB, ICC/IF, IHC-P, ELISA
Reactivity	Human

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	1/500 - 1/2000
ICC/IF	1/100 - 1/500
IHC-P	1/200 - 1/1000
ELISA	1/10000

Not tested in other applications.

Calculated MW	64 kDa. ( Note )

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PROPERTIES

Form	Liquid
Buffer	PBS, 0.05% sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Purified recombinant fragment of human HAS2 (AA: 67-170) expressed in E. Coli.
Purification	Protein G Purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	hyaluronan synthase 2
Cellular Localization	Membrane
Background	Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008]
Database	・ Gene ID: 3037 HAS2 ・ UniProt: Q92819 HAS2

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