抗CYP1A1 [6G5]抗体 | Anti-CYP1A1 [6G5] antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

	WB analysis of human CYP1A1 (AA: 203-461) recombinant protein using GTX60543 CYP1A1 antibody [6G5].
	IHC-P analysis of rectum cancer tissue using GTX60543 CYP1A1 antibody [6G5].
	ELISA analysis of antigen using GTX60543 CYP1A1 antibody [6G5]. Black : Control antigen 100ng Purple : Antigen 10ng Blue : Antigen 50ng Red : Antigen 100ng
	IHC-P analysis of ovarian cancer tissue using GTX60543 CYP1A1 antibody [6G5].

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	6G5
Isotype	IgG1
Application	WB, IHC-P, ELISA
Reactivity	Human

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	1/500 - 1/2000
IHC-P	1/200 - 1/1000
ELISA	1/10000

Not tested in other applications.

Calculated MW	58 kDa. ( Note )

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PROPERTIES

Form	Liquid
Buffer	PBS, 0.05% sodium azide
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Purified recombinant fragment of human CYP1A1(AA : 203-461) expressed in E. Coli.
Purification	Protein G Purified
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	cytochrome P450 family 1 subfamily A member 1 , AHH , AHRR , CP11 , CYP1 , CYPIA1 , P1-450 , P450-C , P450DX
Cellular Localization	Endoplasmic reticulum membrane,Mitochondrion inner membrane,Cytoplasm
Background	This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]
Database	・ Gene ID: 1543 CYP1A1 ・ UniProt: P04798 CYP1A1

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Vazquez-Gomez G et al. Toxicol Lett 2018; 289 : 54-62 Benzo[a]pyrene activates an AhR/Src/ERK axis that contributes to CYP1A1 induction and stable DNA adducts formation in lung cells.	Application : WB Reactivity : Human

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